Search Results
Overview
| Uniprot ID | A0A4X1T4T8 |
|---|---|
| Protein Name | U1 small nuclear ribonucleoprotein C |
| Gene Name | SNRPC |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 3 | *****MPKFYCDYCD |
| 35 | RKHKENVKDYYQKWM |
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region
Protein Sequence
10
MPKFYCDYCD
20
TYLTHDSPSV
30
RKTHCSGRKH
40
KENVKDYYQK
50
WMEEQAQSLI
60
DKTTAAFQQG
70
KIPPTPFSAP
80
PPAGAMIPPP
90
PSLPGPPRPG
100
MMPAPHMGGP
110
PMMPMMGPPP
120
PGMMPVGPGS
130
QHGPPAHLSY
140
NSEQTLSAPG
150
MRPPMGGHMP
160
MMPGPPMMRP
170
PARPMMVPTR
PGMTRPDR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000243 | commitment complex |
| Cellular Component | GO:0005685 | U1 snRNP |
| Cellular Component | GO:0071004 | U2-type prespliceosome |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0030627 | pre-mRNA 5'-splice site binding |
| Molecular Function | GO:0030619 | U1 snRNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0000395 | mRNA 5'-splice site recognition |
| Biological Process | GO:0000387 | spliceosomal snRNP assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.