Search Results

Overview

Uniprot IDA0A4X1TGU4
Protein NameChondroitin sulfate proteoglycan 6
Gene NameSMC3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
56 RRVIGAKKDQYFLDK
579 AFKHVFGKTLICRSM
918 SLKQLFRKLEQCNTE

Function

Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement

Protein Sequence

10 MLLWAEMDLE 20 KVTSFMEGTG 30 PRVISAFVEI 40 IFDNSDNRLP 50 IDKEEVSLRR 60 VIGAKKDQYF 70 LDKKMVTKND 80 VMNLLESAGF 90 SRSNPYYIVK 100 QGKINQMATA 110 PDSQRLKLLR 120 EVAGTRVYDE 130 RKEESISLMK 140 ETEGKREKIN 150 ELLKYIEERL 160 HTLEEEKEEL 170 AQYQKWDKMR 180 RALEYTIYNQ 190 ELNETRAKLD 200 ELSAKRETSG 210 EKSRQLRDAQ 220 QDARDKMEDI 230 ERQVRELKTK 240 ISAMKEEKEQ 250 LSAERQEQIK 260 QRTKLELKAK 270 DLQDELAGNS 280 EQRKRLLKER 290 QKLLEKIEEK 300 QKELAETEPK 310 FNSVKEKEER 320 GIARLAQATQ 330 ERTDLYAKQG 340 RGSQFTSKEE 350 RDKWIKKELK 360 SLDQAINDKK 370 RQIAAIHKDL 380 EDTEANKEKN 390 LEQYNKLDQD 400 LNEVKARVEE 410 LDRKYYEVKN 420 KKDELQSERN 430 YLWREENAEQ 440 QALAAKREDL 450 EKKQQLLRAA 460 TGKAILNGID 470 SINKVLDHFR 480 RKGINQHVQN 490 GYHGIVMNNF 500 ECEPAFYTCV 510 EVTAGNRLFY 520 HIVDSDEVST 530 KILMEFNKMN 540 LPGEVTFLPL 550 NKLDVRDTAY 560 PETNDAIPMI 570 SKLRYNPRFD 580 KAFKHVFGKT 590 LICRSMEVST 600 QLARAFTMDC 610 ITLEGDQVSH 620 RGALTGGYYD 630 TRKSRLELQK 640 DVRKAEEELG 650 ELEAKLNENL 660 RRNIERINNE 670 IDQLMNQMQQ 680 IETQQRKFKA 690 SRDSILSEMK 700 MLKEKRQQSE 710 KTFMPKQRSL 720 QSLEASLHAM 730 ESTRESLKAE 740 LGTDLLSQLS 750 LEDQKRVDAL 760 NDEIRQLQQE 770 NRQLLNERIK 780 LEGIITRVET 790 YLNENLRKRL 800 DQVEQELNEL 810 RETEGGTVLT 820 ATTSELEAIN 830 KRVKDTMARS 840 EDLDNSIDKT 850 EAGIKELQKS 860 MERWKNMEKE 870 HMDAINHDTK 880 ELEKMTNRQG 890 MLLKKKEECM 900 KKIRELGSLP 910 QEAFEKYQTL 920 SLKQLFRKLE 930 QCNTELKKYS 940 HVNKKALDQF 950 VNFSEQKEKL 960 IKRQEELDRG 970 YKSIMELMNV 980 LELRKYEAIQ 990 LTFKQVSKNF 1000 SEVFQKLVPG 1010 GKATLVMKKG 1020 DVEGSQSQDE 1030 GEGSGESERG 1040 SGSQSSVPSV 1050 DQFTGVGIRV 1060 SFTGKQGEMR 1070 EMQQLSGGQK 1080 SLVALALIFA 1090 IQKCDPAPFY 1100 LFDEIDQALD 1110 AQHRKAVSDM 1120 IMELAVHAQF 1130 ITTTFRPELL 1140 ESADKFYGVK 1150 FRNKVSHIDV 1160 ITAEMAKDFV EDDTTHG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0031981 nuclear lumen
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:0051276 chromosome organization
Biological Process GO:0006281 DNA repair
Biological Process GO:0051321 meiotic cell cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.