Search Results

Overview

Uniprot IDA0A4X1TP96
Protein NameEukaryotic translation initiation factor 4 gamma 2
Gene NameEIF4G2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
129 KVRGILNKLTPEKFD
229 RNVDVYDKRENPLLP
248 QRAIAKIKMLGNIKF
275 SILHKCIKTLLEKKK
313 RLDHERAKSLMDQYF
355 EHHWVPRKAFLDNGP
363 AFLDNGPKTINQIRQ
571 NPPLIQEKPAKTSKK
73 GAPQHYPKTAGNSEF
781 KLEKELLKQIKLDPS
797 QTIYKWIKDNISPKL
83 GNSEFLGKTPGQNAQ
922 ITQEFPGKGKALFQV

Function

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases

Protein Sequence

10 MLVVSNFGTL 20 FSFQVFRFSH 30 PFPPHPSINI 40 ILLKILRCQA 50 AKVESAIAEG 60 GASRFSASSG 70 GGGSRGAPQH 80 YPKTAGNSEF 90 LGKTPGQNAQ 100 KWIPARSTRR 110 DDNSAANNSA 120 NEKERHDAIF 130 RKVRGILNKL 140 TPEKFDKLCL 150 ELLNVGVESK 160 LILKGVILLI 170 VDKALEEPKY 180 SSLYAQLCLR 190 LAEDAPNFDG 200 PAAEGQPGQK 210 QSTTFRRLLI 220 SKLQDEFENR 230 TRNVDVYDKR 240 ENPLLPEEEE 250 QRAIAKIKML 260 GNIKFIGELG 270 KLDLIHESIL 280 HKCIKTLLEK 290 KKRVQLKDMG 300 EDLECLCQIM 310 RTVGPRLDHE 320 RAKSLMDQYF 330 ARMCSLMLSK 340 ELPARIRFLL 350 QDTVELREHH 360 WVPRKAFLDN 370 GPKTINQIRQ 380 DAVKDLGVFI 390 PAPMAQGMRS 400 DFFLEGPFMP 410 PRMKMDRDPL 420 GGLADMFGQM 430 PGSGIGTGPG 440 VIQDRFSPTM 450 GRHRSNQLFN 460 GHGGHIMPPT 470 QSQFGEMGGK 480 FMKSQGLSQL 490 YHNQSQGLLS 500 QLQGQSKDMP 510 PRFSKKGQLN 520 ADEISLRPAQ 530 SFLMNKNQVP 540 KLQPQITMIP 550 PSAQPPRTQT 560 PPLGQTPQLG 570 LKTNPPLIQE 580 KPAKTSKKPP 590 PSKEELLKLT 600 ETVVTEYLNS 610 GNANEAVNGV 620 REMRAPKHFL 630 PEMLSKVIIL 640 SLDRSDEDKE 650 KASSLISLLK 660 QEGIATSDNF 670 MQAFLNVLDQ 680 CPKLEVDIPL 690 VKSYLAQFAA 700 RAIISELVSI 710 SELAQPLESG 720 THFPLFLLCL 730 QQLAKLQDRE 740 WLTELFQQSK 750 VNMQKMLPEI 760 DQNKDRMLEI 770 LEGKGLSFLF 780 PLLKLEKELL 790 KQIKLDPSPQ 800 TIYKWIKDNI 810 SPKLHVDKGF 820 VNILMTSFLQ 830 YISSEVNPPS 840 DETDSSSAPS 850 KEQLEQEKQL 860 LLSFKPVMQK 870 FLHDHVDLQV 880 SALYALQVHC 890 YNSNFPKGML 900 LRFFVHFYDM 910 EIIEEEAFLA 920 WKEDITQEFP 930 GKGKALFQVN 940 QWLTWLETAE EEESEEEAD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016281 eukaryotic translation initiation factor 4F complex
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0008135 translation factor activity, RNA binding
Molecular Function GO:0003743 translation initiation factor activity
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0006446 regulation of translational initiation
Biological Process GO:0006413 translational initiation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.