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Overview

Uniprot IDA0A4X1TXD8
Protein NameCoatomer subunit beta'
Gene NameCOPB2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
123 IKLWDWDKKWSCSQV
161 ASLDRTIKVWQLGSS
205 GADDRLVKIWDYQNK
311 NGKIIWAKHSEVQQA
406 RESNSVVKIFKNFKE
622 RVAHFLEKQGFKQQA
666 AESEQKWKQLAELAI
774 LWRENLSKVNQKAAE
817 HADLWPAKQYPLVTP

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 MLKLTARSDR 20 VKSVDLHPTE 30 PWMLASLYNG 40 SVCVWNHETQ 50 TLVKTFEVCD 60 LPVRAAKFVA 70 RKNWVVTGAD 80 DMQIRVFNYN 90 TLERVHMFEA 100 HSDYIRCIAV 110 HPTQPFILTS 120 SDDMLIKLWD 130 WDKKWSCSQV 140 FEGHTHYVMQ 150 IVINPKDNNQ 160 FASASLDRTI 170 KVWQLGSSSP 180 NFTLEGHEKG 190 VNCIDYYSGG 200 DKPYLISGAD 210 DRLVKIWDYQ 220 NKTCVQTLEG 230 HAQNVSCASF 240 HPELPIIITG 250 SEDGTVRIWH 260 SSTYRLESTL 270 NYGMERVWCV 280 ASLRGSNNVA 290 LGYDEGSIIV 300 KLGREEPAMS 310 MDANGKIIWA 320 KHSEVQQANL 330 KAMGDAEIKD 340 GERLPLAVKD 350 MGSCEIYPQT 360 IQHNPNGRFV 370 VVCGDGEYII 380 YTAMALRNKS 390 FGSAQEFAWA 400 HDSSEYAIRE 410 SNSVVKIFKN 420 FKEKKSFKPD 430 FGAESECIYG 440 GFLLGVRSVN 450 GLAFYDWDNT 460 ELIRRIEIQP 470 KHIFWSDSGE 480 LVCIATEESF 490 FILKYLSEKV 500 LAAQETHEGV 510 TEDGIEDGFE 520 VLGEIQEIVK 530 TGLWVGDCFI 540 YTSSVNRLNY 550 YVGGEIVTIA 560 HLDRTMYLLG 570 YIPKDNRLYL 580 GDKELNIVSY 590 SLLVSVLEYQ 600 TAVMRRDFSM 610 ADKVLPTIPK 620 EQRTRVAHFL 630 EKQGFKQQAL 640 TVSTDPEHRF 650 ELALQLGELK 660 IAYQLAVEAE 670 SEQKWKQLAE 680 LAISKCQFGL 690 AQECLHHAQD 700 YGGLLLLATA 710 SGNASMVNKL 720 AEGAERDGKN 730 NVAFMSYFLQ 740 GKLDACLELL 750 IRTGRLPEAA 760 FLARTYLPSQ 770 VSRVVKLWRE 780 NLSKVNQKAA 790 ESLADPTEYE 800 NLFPGLKEAF 810 VVEEWVKETH 820 ADLWPAKQYP 830 LVTPNEERNV 840 MEEAKGFQPS 850 RSAAQQELAG 860 KPASPTPVIM 870 ATHTGNKEEK 880 QSLLELEVDL 890 DNLELEDIDT 900 TDINLDEDIL DD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030663 COPI-coated vesicle membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0030117 membrane coat
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.