Search Results
Overview
| Uniprot ID | A0A4X1U068 |
|---|---|
| Protein Name | Ubiquitin-conjugating enzyme E2 C |
| Gene Name | UBE2C |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | CLDILKDKWSALYDV |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
Protein Sequence
10
MASQNRDPAA
20
ASFAAARKGA
30
EPSGGAARGP
40
VGKRLQQELM
50
TLMMSGDKGI
60
SAFPESDNLF
70
KWVGTIHGAA
80
GTVYEDLRYK
90
LSLEFPSGYP
100
YNAPTVKFLT
110
PCYHPNVDTQ
120
GNICLDILKD
130
KWSALYDVRT
140
ILLSIQSLLG
150
EPNIDSPLNT
160
HAAELWKNPT
170
AFKKYLQETY
SKQVSSQEP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005680 | anaphase-promoting complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Molecular Function | GO:0044389 | ubiquitin-like protein ligase binding |
| Biological Process | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0010458 | exit from mitosis |
| Biological Process | GO:0010994 | free ubiquitin chain polymerization |
| Biological Process | GO:0031536 | positive regulation of exit from mitosis |
| Biological Process | GO:0045842 | positive regulation of mitotic metaphase/anaphase transition |
| Biological Process | GO:0070979 | protein K11-linked ubiquitination |
| Biological Process | GO:0070936 | protein K48-linked ubiquitination |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0030071 | regulation of mitotic metaphase/anaphase transition |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.