Search Results
Overview
| Uniprot ID | A0A4X1U8P5 |
|---|---|
| Protein Name | Diablo IAP-binding mitochondrial protein |
| Gene Name | DIABLO |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 189 | RSHIQLVKSQVQEVR |
| 201 | EVRQLSQKAETKLAE |
Function
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases
Protein Sequence
10
MAALRSWLSR
20
NVAFFFRYRQ
30
CVPVVANLKK
40
RCFSELIRPW
50
HKTVVVGLGV
60
TLCAVPIAQK
70
SEPHSLSNDA
80
LMRRAVSLVT
90
DSTSTFLSQT
100
TYALIEAITE
110
YTKAVYTLIS
120
LYRQYTSLLG
130
KMNSQEEDEV
140
WQVIIGARVE
150
MTSKQQEYLK
160
LETTWMTAVS
170
LSEMAAEAAY
180
QTGADQASIT
190
ARSHIQLVKS
200
QVQEVRQLSQ
210
KAETKLAEAQ
220
TEELRQKTQE
230
EGHESAEPEQ
EAYLRED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035631 | CD40 receptor complex |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Biological Process | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process | GO:0051402 | neuron apoptotic process |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.