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Overview

Uniprot IDA0A4X1UCH0
Protein NamePlatelet-activating factor acetylhydrolase IB subunit alpha
Gene NamePAFAH1B1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
147 GDFERTLKGHTDSVQ
266 RVWVVATKECKAELR
269 VVATKECKAELREHE
360 ILSCADDKTLRVWDY
368 TLRVWDYKNKRCMKT
46 MNEELDKKYAGLLEK
54 YAGLLEKKWTSVIRL

Function

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position

Protein Sequence

10 MVLSQRQRDE 20 LNRAIADYLR 30 SNGYEEAYSV 40 FKKEAELDMN 50 EELDKKYAGL 60 LEKKWTSVIR 70 LQKKVMELES 80 KLNEAKEEFT 90 SGGPLGQKRD 100 PKEWIPRPPE 110 KYALSGHRSP 120 VTRVIFHPVF 130 SVMVSASEDA 140 TIKVWDYETG 150 DFERTLKGHT 160 DSVQDISFDH 170 SGKLLASCSA 180 DMTIKLWDFQ 190 GFECIRTMHG 200 HDHNVSSVAI 210 MPNGDHIVSA 220 SRDKTIKMWE 230 VQTGYCVKTF 240 TGHREWVRMV 250 RPNQDGTLIA 260 SCSNDQTVRV 270 WVVATKECKA 280 ELREHEHVVE 290 CISWAPESSY 300 SSISEATGSE 310 TKKSGKPGPF 320 LLSGSRDKTI 330 KMWDVSTGMC 340 LMTLVGHDNW 350 VRGVLFHSGG 360 KFILSCADDK 370 TLRVWDYKNK 380 RCMKTLNAHE 390 HFVTSLDFHK 400 TAPYVVTGSV 410 DQTVKVWECR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0000235 astral microtubule
Cellular Component GO:1904115 axon cytoplasm
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0031252 cell leading edge
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005881 cytoplasmic microtubule
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005875 microtubule associated complex
Cellular Component GO:0031514 motile cilium
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0032420 stereocilium
Molecular Function GO:0070840 dynein complex binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051010 microtubule plus-end binding
Molecular Function GO:0051219 phosphoprotein binding
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0060117 auditory receptor cell development
Biological Process GO:0048854 brain morphogenesis
Biological Process GO:0051301 cell division
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0090102 cochlea development
Biological Process GO:0021540 corpus callosum morphogenesis
Biological Process GO:0043622 cortical microtubule organization
Biological Process GO:0000132 establishment of mitotic spindle orientation
Biological Process GO:0042249 establishment of planar polarity of embryonic epithelium
Biological Process GO:0007281 germ cell development
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0090176 microtubule cytoskeleton organization involved in establishment of planar polarity
Biological Process GO:0031023 microtubule organizing center organization
Biological Process GO:0051012 microtubule sliding
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:0001764 neuron migration
Biological Process GO:0007097 nuclear migration
Biological Process GO:0061003 positive regulation of dendritic spine morphogenesis
Biological Process GO:0040019 positive regulation of embryonic development
Biological Process GO:0038026 reelin-mediated signaling pathway
Biological Process GO:0070507 regulation of microtubule cytoskeleton organization
Biological Process GO:0008090 retrograde axonal transport
Biological Process GO:0047496 vesicle transport along microtubule

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.