Search Results
Overview
| Uniprot ID | A0A4X1UE23 |
|---|---|
| Protein Name | Protein disulfide-isomerase A6 |
| Gene Name | PDIA6 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | IKIFGSNKNRPEDYQ |
| 147 | GGGYSSGKQGRSEGS |
| 157 | RSEGSGKKDVIELTD |
| 205 | AAAATEVKEQTKGKV |
| 213 | EQTKGKVKLAAVDAT |
| 238 | IRGFPTIKIFQKGES |
| 242 | PTIKIFQKGESPVDY |
| 365 | AINARKMKFALLKGS |
| 63 | QRLTPEWKKVATALK |
| 64 | RLTPEWKKVATALKD |
| 70 | KKVATALKDVVKVGA |
| 74 | TALKDVVKVGAVDAD |
| 82 | VGAVDADKHQSLGGQ |
Function
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin
Protein Sequence
10
VALGLMSCTL
20
FVAVNGLYSS
30
SDDVIELTPS
40
NFNREVIQSD
50
SLWLVEFYAP
60
WCGHCQRLTP
70
EWKKVATALK
80
DVVKVGAVDA
90
DKHQSLGGQY
100
GVQGFPTIKI
110
FGSNKNRPED
120
YQGGRTGEAI
130
VDAALSALRQ
140
LVKDRLGGRG
150
GGYSSGKQGR
160
SEGSGKKDVI
170
ELTDDTFDKN
180
VLDSEDVWMV
190
EFYAPWCGHC
200
KNLEPEWAAA
210
ATEVKEQTKG
220
KVKLAAVDAT
230
VNQVLASRYG
240
IRGFPTIKIF
250
QKGESPVDYD
260
GGRTRSDIVT
270
RALDLFSDNA
280
PPPELLEIIS
290
EDVAKKSCEE
300
HQLCVVAVLP
310
HILDTGAAGR
320
NSYLEVLLKL
330
ADKYKKKMWG
340
WLWTEAGAQT
350
ELEHALGIGG
360
FGYPAMAAIN
370
ARKMKFALLK
380
GSFSEQGINE
390
FLRELSFGRG
400
STAPVGGGAF
410
PAISTREPWD
420
GKDGELPVED
430
DIDLSDVELD
DLEKDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.