Overview
| Uniprot ID | A0A4X1UE49 |
|---|
| Protein Name | Cyclin-dependent kinase 14 |
|---|
| Gene Name | CDK14 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 118 |
NGKLVALKVIRLQEE |
Function
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport
Protein Sequence
10
MSTRNCPGMD
20
SMIKPLDTIP
30
EDKKVRVQRT
40
QSTFDPFEKP
50
ANQVKRVHSE
60
NNACINFKTS
70
SAGKESPKVR
80
RHSSPSSPTS
90
PKFGKADSYE
100
KLEKLGEGSY
110
ATVYKGKSKV
120
NGKLVALKVI
130
RLQEEEGTPF
140
TAIREASLLK
150
GLKHANIVLL
160
HDIIHTKETL
170
TLVFEYVHTD
180
LCQYMDKHPG
190
GLHPENVKLF
200
LFQLLRGLSY
210
IHQRYILHRD
220
LKPQNLLISD
230
TGELKLADFG
240
LARAKSVPSH
250
TYSNEVVTLW
260
YRPPDVLLGS
270
TEYSTCLDMW
280
GVGCIFVEMI
290
QGVAAFPGMK
300
DIQDQLERIF
310
LVLGTPNEDT
320
WPGVHSLPHF
330
KPERFTLYSS
340
KNLRQAWNKL
350
SYVNHAEDLA
360
SKLLQCSPKN
370
RLSAQAALSH
380
EYFSDLPPRL
390
WELTDMSSIF
400
TVPNVRLQPE
410
AGESTRAFGK
420
NNSYGKSLSN
SKH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004693 |
cyclin-dependent protein serine/threonine kinase activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.