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Overview

Uniprot IDA0A4X1UEY4
Protein NameUbiquitin-protein ligase E3A
Gene NameUBE3A
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
79 ELYKINAKLCDPHPS
822 APVGGLGKLKMIIAK

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates

Protein Sequence

10 MATACKRSSG 20 EPQSDDIEAS 30 RMKRAAAKHL 40 IERYYHQLTE 50 GCGNEACTNE 60 FCASCPTFRR 70 MDNNAAAIKA 80 LELYKINAKL 90 CDPHPSKKGA 100 SSAYLENSKG 110 APNNCSDIKM 120 NRKEGQGARD 130 DFKDVTYLTE 140 ETVYEILELC 150 REREDYSPLI 160 RVIGRVFSSA 170 EALVQSFRKV 180 KQHTKEELKS 190 LQGKDEDKDE 200 DEKEKAACSA 210 AAMEEDSEAS 220 SSRISDGSQG 230 DNNLQKLGPD 240 DVSVDIEAIR 250 RVYIRLLSNE 260 KIETAFLNAL 270 VYLSPNVECD 280 LTYHNVYSRD 290 PNYLNLFIIV 300 MENRNLHSPE 310 YLEMALPLFC 320 KAMSKLPLAA 330 QGKLVRLWSK 340 YNADQIRRMM 350 ETFQQLITYK 360 VISTDFNNRN 370 LVNDDDAIVA 380 ASKCLKMVYY 390 ANVVGGEVDT 400 NHNEEDDEEP 410 IPESSELTLQ 420 ELLGEERRNK 430 KGPRVDPLET 440 ELGVKTLDCR 450 KPLIPFEEFI 460 NEPLNDVLEM 470 DKDYTFFKVE 480 TENKFSFMTC 490 PFILNAVTKN 500 LGLYYDNRIR 510 MYSERRITVL 520 YSLVQGQQLN 530 PYLRLKVRRD 540 HIIDDALVRL 550 EMIAMENPAD 560 LKKQLYVEFE 570 GEQGVDEGGV 580 SKEFFQLVVE 590 EIFNPDIGMF 600 TYDESTKLFW 610 FNPSSFETEG 620 QFTLIGIVLG 630 LAIYNNCILD 640 VHFPMVVYRK 650 LMGKKGTFRD 660 LGDSHPVLYQ 670 SLKDLLEYEG 680 SVEDDMMITF 690 QISQTDLFGN 700 PMMYDLKENG 710 DKIPITNENR 720 KEFVNLYSDY 730 ILNKSVEKQF 740 KAFRRGFHMV 750 TNESPLKYLF 760 RPEEIELLIC 770 GSRNLDFQAL 780 EETTEYDGGY 790 TRDSVVIREF 800 WEIVHSFTDE 810 QKRLFLQFTT 820 GTDRAPVGGL 830 GKLKMIIAKN 840 GPDTERLPTS 850 HTCFNVLLLP 860 EYSSKEKLKE 870 RLLKAITYAK GFGML

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0048513 animal organ development
Biological Process GO:0031398 positive regulation of protein ubiquitination
Biological Process GO:0050847 progesterone receptor signaling pathway
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:2000058 regulation of ubiquitin-dependent protein catabolic process
Biological Process GO:0032570 response to progesterone
Biological Process GO:0048511 rhythmic process
Biological Process GO:0048731 system development
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.