Overview
| Uniprot ID | A0A4X1UGW3 |
|---|
| Protein Name | Mitochondrial import receptor subunit TOM20 homolog |
|---|
| Gene Name | TOMM20 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 56 |
KERAGLSKLPDLKDA |
Function
Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOMM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases
Protein Sequence
10
MVGRNSAIAA
20
GVCGALFIGY
30
CIYFDRKRRS
40
DPNFKNRLRE
50
RRKKQKLAKE
60
RAGLSKLPDL
70
KDAEAVQKFF
80
LEEIQLGEEL
90
LAQGEYEKGV
100
DHLTNAIAVC
110
GQPQQLLQVL
120
QQTLPPPVFQ
130
MLLTKLPTIS
140
QRIVSAQSLA
EDDVE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005742 |
mitochondrial outer membrane translocase complex |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0030150 |
protein import into mitochondrial matrix |
| Biological Process |
GO:0006605 |
protein targeting |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.