Overview
| Uniprot ID | A0A4X1UIB2 |
|---|
| Protein Name | Mitochondrial fission 1 protein |
|---|
| Gene Name | FIS1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 25 |
ERKFQSEKAAGSVSK |
| 46 |
AWCLVRSKYNDDIRK |
Function
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis
Protein Sequence
10
MEAVLNELVS
20
VEDLLKFERK
30
FQSEKAAGSV
40
SKSTQFEYAW
50
CLVRSKYNDD
60
IRKGLALLEE
70
LLPKGSKEEQ
80
RDYVFYLAVG
90
NYRLKEYEKA
100
LKYVRGLLQT
110
EPQNNQAKEL
120
EGLIDKAMKK
130
DGLVGMAIVG
140
GMALGVAGLA
150
GLIGLAVSKS
KS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005778 |
peroxisomal membrane |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0000266 |
mitochondrial fission |
| Biological Process |
GO:1903579 |
negative regulation of ATP metabolic process |
| Biological Process |
GO:2000192 |
negative regulation of fatty acid transport |
| Biological Process |
GO:0016559 |
peroxisome fission |
| Biological Process |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process |
GO:0006626 |
protein targeting to mitochondrion |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.