Search Results
Overview
| Uniprot ID | A0A4X1UIU6 |
|---|---|
| Protein Name | Translation initiation factor eIF2B subunit alpha |
| Gene Name | EIF2B1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 145 | LEAAVAAKKRFSVYI |
Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed
Protein Sequence
10
MDDKELIEYF
20
KSQMKEDPDM
30
ASAVAAIRTL
40
LEYLKRDKGE
50
TIQGLRANLT
60
SAIETLCGVD
70
SSVAVSSGGE
80
LFLRFISLTS
90
LEYSDYSKCK
100
KIMIERGEIF
110
LRRISLSRKK
120
IADMCHTFIK
130
DGARILTHAY
140
SRVVLRVLEA
150
AVAAKKRFSV
160
YITESQPDLS
170
GQVSFHLVLC
180
LAVLLKSKLR
190
IRIYFKRDQN
200
MPQICHQLAL
210
PLTVPDSGPG
220
RKTTGEFEVG
HSTG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0003743 | translation initiation factor activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.