Overview
| Uniprot ID | A0A4X1UK62 |
|---|
| Protein Name | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | ACADM |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 274 |
RALDEATKYALERKT |
Function
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16
Protein Sequence
10
MAAMFRRSCR
20
VLRSLSHFGW
30
RSQHTKAVPQ
40
CEPGSGFSFE
50
LTEQQKEFQA
60
TARKFAREEI
70
IPVAAEYDRT
80
GEYPVPLLKR
90
AWELGLMNTH
100
IPESFGGLGL
110
GIIDSCLITE
120
ELAYGCTGVQ
130
TAIEANTLGA
140
YCVTEPGAGS
150
DVAGIKTKAE
160
KKGDEYIING
170
QKMWITNGGK
180
ANWYFLLARS
190
DPDPKAPASK
200
AFTGFIVEAD
210
TPGVQIGRKE
220
INMGQRCSDT
230
RGIVFEDVRV
240
PKENVLTGEG
250
AGFKIAMGTF
260
DKTRPPVAAG
270
AVGLAQRALD
280
EATKYALERK
290
TFGKLLAEHQ
300
GISFLLADMA
310
MKVELARLSY
320
QRAAWEIDSG
330
RRNTYYASIA
340
KAYAADIANQ
350
LATDAVQVFG
360
GNGFNTEYPV
370
EKLMRDAKIY
380
QIYEGTAQIQ
390
RIIIAREHIG
RYKN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0070991 |
medium-chain fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0045329 |
carnitine biosynthetic process |
| Biological Process |
GO:0019254 |
carnitine metabolic process, CoA-linked |
| Biological Process |
GO:0033539 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| Biological Process |
GO:0005978 |
glycogen biosynthetic process |
| Biological Process |
GO:0051793 |
medium-chain fatty acid catabolic process |
| Biological Process |
GO:0006111 |
regulation of gluconeogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.