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Overview

Uniprot IDA0A4X1UNE5
Protein NameRNA helicase aquarius
Gene NameAQR
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
762 SGKGKKRKDADGEDE

Function

Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing

Protein Sequence

10 MTAPAQPKKI 20 VAPTVSQINA 30 EFVTQLACKY 40 WAPHIKKKSP 50 FDIKVIEDIY 60 EKEIVKSRFA 70 IRKIMLLEFS 80 QYLENYLWMN 90 YSPEVSSKAY 100 LMSICCMVNE 110 KFRENVPAWE 120 TFKKKPDHFP 130 FFFKCILKAA 140 LAETDGEFSL 150 HEQTVLLLFL 160 DHCFNSLEVD 170 LIRSQVQQLI 180 SLPMWMGLQP 190 ARLELELKKT 200 PKLRKFWNLI 210 KKNDEKMDPE 220 AREQAYQERK 230 FLSQLIQKFI 240 SVLKSVPLSD 250 PVTMDKVHYC 260 ERFIELMIDL 270 EALLPTRRWF 280 NTILDDSHLL 290 VHCYLSNLVH 300 REEDGHLFSQ 310 LLDMLKFYTG 320 FEINDQTGNA 330 LTENEMTTIH 340 YDRITSLQRA 350 AFAHFPELYD 360 FALSNVAEVD 370 TRESLVKFFG 380 PLSSNTLHQV 390 ASYLCLLPTL 400 PKAEDTTFDK 410 EFLLELLVSR 420 HERRISQIQQ 430 LNQMPLYPTE 440 KIIWDENIVP 450 TEYYSGEGCL 460 ALPKLNLQFL 470 TLHDYLLRNF 480 NLFRLESTYE 490 IRQDIEDSVS 500 RMKPWQSEYG 510 GVVFGGWARM 520 AQPIVAFTVV 530 EVAKPNIGEN 540 WPTRVRADVT 550 INLNVRDHIK 560 DEWEGLRKHD 570 VCFLITVRPT 580 KPYGTKFDRR 590 RPFIEQVGLV 600 YVRGCEIQGM 610 LDDKGRVIED 620 GPEPRPNLRG 630 ESRTFRVFLD 640 PNQYQQDMTN 650 TIQNGAEDVY 660 ETFNIIMRRK 670 PKENNFKAVL 680 ETIRNLMNTD 690 CVVPDWLHDI 700 ILGYGDPSSA 710 HYSKMPNQIA 720 TLDFNDTFLS 730 IEHLKASFPG 740 HNVKVTVDDP 750 ALQIPPFRIT 760 FPVRSGKGKK 770 RKDADGEDED 780 TEEAKTLIVE 790 PHVIPNRGPY 800 PYNQPKRNTI 810 QFTHTQIEAI 820 RAGMQPGLTM 830 VVGPPGTGKT 840 DVAVQIISNI 850 YHNFPEQRTL 860 IVTHSNQALN 870 QLFEKIMALD 880 IDERHLLRLG 890 HGEEELETEK 900 DFSRYGRVNY 910 VLARRIELLE 920 EVKRLQKSLG 930 VPGDASYTCE 940 TAGYFFLYQV 950 MSRWEEYISK 960 VKNKGRSYEE 970 DMEIAEGCFR 980 HIKKIFTQLE 990 EFRASELLRS 1000 GLDRSKYLLV 1010 KEAKIIAMTC 1020 THAALKRHDL 1030 VKLGFKYDNI 1040 LMEEAAQILE 1050 IETFIPLLLQ 1060 NPQDGFSRLK 1070 RWIMIGDHHQ 1080 LPPVIKNMAF 1090 QKYSNMEQSL 1100 FTRFVRVGVP 1110 TVDLDAQGRA 1120 RASLCNLYNW 1130 RYKNLGNLPH 1140 VQLLPEFSTA 1150 NAGLLYDFQL 1160 INVEDFQGVG 1170 ESEPNPYFYQ 1180 NLGEAEYVVA 1190 LFMYMCLLGY 1200 PADKISILTT 1210 YNGQKHLIRD 1220 IINRRCGSNP 1230 LIGRPNKVTT 1240 VDRFQGQQND 1250 YILLSLVRTR 1260 AVGHLRDVRR 1270 LVVAMSRARL 1280 GLYIFARVSL 1290 FQNCFELTPA 1300 FSQLTARPLH 1310 LHIIPTEPFP 1320 TSRKNGERPS 1330 HEVQIIKNMP 1340 QMANFVYNMY 1350 MHLIQTTHHY 1360 HQTLLQLPPA 1370 MVEEGEEVQS 1380 QDTELETEEE 1390 AMPAPADIMP 1400 TLMDASSSQE 1410 ASASQTEPTS 1420 NETETTSSQT 1430 GADSNPEATP 1440 AESKITATAA 1450 GPVATPAENN 1460 TPPDATSAPG ETK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.