Overview
| Uniprot ID | A0A4X1UQD7 |
|---|
| Protein Name | Protein SEC13 homolog |
|---|
| Gene Name | SEC13 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 183 |
QKPNYIKKFASGGCD |
| 40 |
CSSDRSVKIFDVRNG |
Function
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex
Protein Sequence
10
GEMVSVINTV
20
DTSHEDMIHD
30
AQMDYYGTRL
40
ATCSSDRSVK
50
IFDVRNGGQI
60
LIADLRGHEG
70
PVWQVAWAHP
80
MYGNILASCS
90
YDRKVIIWKE
100
ENGTWEKTHE
110
HTGHDSSVNS
120
VCWAPHDYGL
130
ILACGSSDGA
140
ISLLTYTGLG
150
QWEVKKINNA
160
HTIGCNAVSW
170
APAVVPGSLI
180
DQPSGQKPNY
190
IKKFASGGCD
200
NLIKLWKEEE
210
DGQWKEEQKL
220
EAHSDWVRDV
230
AWAPSIGLPT
240
STIASCSQDG
250
RVFIWTCDDA
260
SGNTWSPKLL
270
HKFNDVVWHV
280
SWSITANILA
290
VSGGDNKVTL
300
WKESVDGQWV
310
CISDVNKGQG
320
SVSTSITEGQ
QNEQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030127 |
COPII vesicle coat |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0031080 |
nuclear pore outer ring |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0090114 |
COPII-coated vesicle budding |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:0032008 |
positive regulation of TOR signaling |
| Biological Process |
GO:0032527 |
protein exit from endoplasmic reticulum |
| Biological Process |
GO:0006606 |
protein import into nucleus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.