Overview
| Uniprot ID | A0A4X1UR80 |
|---|
| Protein Name | Motile sperm domain-containing protein 2 |
|---|
| Gene Name | MOSPD2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 370 |
VRTTAPEKYRVKPSN |
Function
Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins. In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis. The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Promotes migration of primary monocytes and neutrophils, in response to various chemokines
Protein Sequence
10
MRYLDLSCGS
20
GDGSCDHVRE
30
RNHGRDKSDK
40
YDPRDVERLQ
50
QDDNWVESYL
60
CWRHNIVDET
70
LKMLDESFQW
80
RKEMSVNDLT
90
EASIPRWLLE
100
IGGIYLHGYD
110
KEGNKLFWIR
120
VKYHIKDHKT
130
ILDKKKLIAF
140
WLERYAKREN
150
GKPVTVMFDL
160
SETGINSIDM
170
DFVRFIINCF
180
KVYYPKYLSK
190
MVIFDMPWIM
200
NAAFKIVKSW
210
LGPEAVSLLK
220
FTTKNDVQDY
230
VSVEYLPPHM
240
GGSDPFKYSY
250
PPLVDDDFQT
260
PLCENGPIAS
270
EDEASSKEDL
280
ESDGKESLET
290
VSNEEQAAFL
300
KKSNVTEPTS
310
KAEESEKVDS
320
KMRAFKKPLS
330
VFKGPLLHIS
340
PAEELYFGST
350
ESGEKKALIV
360
LTNVTKNIVA
370
FKVRTTAPEK
380
YRVKPSNSSC
390
DPGASIDIVV
400
SPHGGLTVSA
410
QDRFLIMAAE
420
MEQSSGTGQT
430
ELTQFWKEVP
440
RNKVMEHRLR
450
CHIVESSKPT
460
TLTLKDHAFN
470
MSDKTNEDLF
480
LQLNRLLESN
490
RKLEDQVQRC
500
VWFQQLLLSL
510
TVLSLAFVIS
FFYLLYS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Biological Process |
GO:0006935 |
chemotaxis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.