Overview
| Uniprot ID | A0A4X1USJ2 |
|---|
| Protein Name | Protein SEC13 homolog |
|---|
| Gene Name | SEC13 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 166 |
QKPNYIKKFASGGCD |
| 23 |
CSSDRSVKIFDVRNG |
Function
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex
Protein Sequence
10
MHDAQMDYYG
20
TRLATCSSDR
30
SVKIFDVRNG
40
GQILIADLRG
50
HEGPVWQVAW
60
AHPMYGNILA
70
SCSYDRKVII
80
WKEENGTWEK
90
THEHTGHDSS
100
VNSVCWAPHD
110
YGLILACGSS
120
DGAISLLTYT
130
GLGQWEVKKI
140
NNAHTIGCNA
150
VSWAPAVVPG
160
SLIDQPSGQK
170
PNYIKKFASG
180
GCDNLIKLWK
190
EEEDGQWKEE
200
QKLEAHSDWV
210
RDVAWAPSIG
220
LPTSTIASCS
230
QDGRVFIWTC
240
DDASGNTWSP
250
KLLHKFNDVV
260
WHVSWSITAN
270
ILAVSGGDNK
280
VTLWKESVDG
290
QWVCISDVNK
300
GQGSVSTSIT
EGQQNEQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.