Search Results
Overview
| Uniprot ID | A0A4X1UV69 |
|---|---|
| Protein Name | DNA repair nuclease/redox regulator APEX1 |
| Gene Name | APEX1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | LSRQCPLKVSYGIGE |
| 228 | RNPKGNKKNAGFTPQ |
| 63 | SGKSATLKICSWNVD |
| 7 | *MPKRGKKAAVAEDG |
| 79 | LRAWIKKKGLDWVKE |
Function
Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends
Protein Sequence
10
MPKRGKKAAV
20
AEDGDEPKSE
30
PEAKKSKAGA
40
KKTEKEAAGD
50
GAVLYEDPPD
60
QKTSPSGKSA
70
TLKICSWNVD
80
GLRAWIKKKG
90
LDWVKEEAPD
100
ILCLQETKCS
110
ENKLPAELQE
120
LSGLPHQYWS
130
APSDKEGYSG
140
VGLLSRQCPL
150
KVSYGIGEEE
160
HDQEGRVIVA
170
EFDAFVLVTA
180
YVPNAGRGLV
190
RLEYRQRWDE
200
AFRKFLKGLA
210
SHKPLVLCGD
220
LNVAHEEIDL
230
RNPKGNKKNA
240
GFTPQERQGF
250
GELLQAVPLA
260
DSFRHLYPNT
270
AYAYTFWTYM
280
MNARSKNVGW
290
RLDYFLLSHS
300
LLPALCDSKI
310
RSKALGSDHC
PITLYLAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0052720 | class II DNA-(apurinic or apyrimidinic site) endonuclease activity |
| Molecular Function | GO:0033892 | deoxyribonuclease (pyrimidine dimer) activity |
| Molecular Function | GO:0140431 | DNA-(abasic site) binding |
| Molecular Function | GO:0003906 | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| Molecular Function | GO:0008311 | double-stranded DNA 3'-5' DNA exonuclease activity |
| Molecular Function | GO:0003691 | double-stranded telomeric DNA binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0090580 | phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands |
| Molecular Function | GO:0008081 | phosphoric diester hydrolase activity |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0006284 | base-excision repair |
| Biological Process | GO:0006308 | DNA catabolic process |
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0044029 | positive regulation of gene expression via chromosomal CpG island demethylation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0097698 | telomere maintenance via base-excision repair |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.