Overview
| Uniprot ID | A0A4X1UWZ5 |
|---|
| Protein Name | Proteasome subunit alpha type |
|---|
| Gene Name | PSMA4 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 205 |
NKTMDVSKLSAEKVE |
| 210 |
VSKLSAEKVEIATLT |
| 231 |
VIRVLKQKEVEQLIK |
| 238 |
KEVEQLIKKHEEEEA |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MSRRYDSRTT
20
IFSPEGRLYQ
30
VEYAMEAIGH
40
AGTCLGILAN
50
DGVLLAAERR
60
NIHKLLDEVF
70
FSEKIYKLNE
80
DMACSVAGIT
90
SDANVLTNEL
100
RLIAQRYLLQ
110
YQEPIPCEQL
120
VTALCDIKQA
130
YTQFGGKRPF
140
GVSLLYIGWD
150
KHYGFQLYQS
160
DPSGNYGGWK
170
ATCIGNNSAA
180
AVSMLKQDYK
190
EGEMTLKSAL
200
ALAIKVLNKT
210
MDVSKLSAEK
220
VEIATLTREN
230
GKTVIRVLKQ
240
KEVEQLIKKH
250
EEEEAKAERE
260
KKEKEQKEKD
K
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.