Overview
| Uniprot ID | A0A4X1UWZ6 |
|---|
| Protein Name | Proteasome subunit beta |
|---|
| Gene Name | PSMA4 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 198 |
NKTMDVSKLSAEKVE |
| 203 |
VSKLSAEKVEIATLT |
| 224 |
VIRVLKQKEVEQLIK |
| 231 |
KEVEQLIKKHEEEEA |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MHHRAVSQSR
20
LYQVEYAMEA
30
IGHAGTCLGI
40
LANDGVLLAA
50
ERRNIHKLLD
60
EVFFSEKIYK
70
LNEDMACSVA
80
GITSDANVLT
90
NELRLIAQRY
100
LLQYQEPIPC
110
EQLVTALCDI
120
KQAYTQFGGK
130
RPFGVSLLYI
140
GWDKHYGFQL
150
YQSDPSGNYG
160
GWKATCIGNN
170
SAAAVSMLKQ
180
DYKEGEMTLK
190
SALALAIKVL
200
NKTMDVSKLS
210
AEKVEIATLT
220
RENGKTVIRV
230
LKQKEVEQLI
240
KKHEEEEAKA
250
EREKKEKEQK
EKDK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Biological Process |
GO:0051603 |
proteolysis involved in protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.