Overview
| Uniprot ID | A0A4X1UX31 |
|---|
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
|---|
| Gene Name | PRKACB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 28 |
KEFLAKAKEDFLKKW |
| 314 |
WIAIYQRKVEAPFIP |
| 97 |
IEHTLNEKRILQAVN |
Function
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR
Protein Sequence
10
MGLSRKSSEA
20
SACSSSEVSV
30
KEFLAKAKED
40
FLKKWENPAP
50
NNAGLEDFER
60
KKTLGTGSFG
70
RVMLVKHKAT
80
EQYYAMKILD
90
KQKVVKLKQI
100
EHTLNEKRIL
110
QAVNFPFLVR
120
LEYSFKDNSN
130
LYMVMEYVPG
140
GEMFSHLRRI
150
GRFSEPHARF
160
YAAQIVLTFE
170
YLHSLDLIYR
180
DLKPENLLID
190
HQGYIQVTDF
200
GFAKRVKGRT
210
WTLCGTPEYL
220
APEIILSKGY
230
NKAVDWWALG
240
VLIYEMAAGY
250
PPFFADQPIQ
260
IYEKIVSGKV
270
RFPSHFSSDL
280
KDLLRNLLQV
290
DLTKRFGNLK
300
NGVSDIKTHK
310
WFATTDWIAI
320
YQRKVEAPFI
330
PKFRGSGDTS
340
NFDDYEEEDI
350
RVSITEKCGK
EFCEF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004691 |
cAMP-dependent protein kinase activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.