Search Results
Overview
| Uniprot ID | A0A4X1UY24 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase |
| Gene Name | UCHL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 119 | QFLSETEKLSPEDRA |
| 131 | DRAKCFEKNEAIQAA |
| 195 | SLLQDAAKVCREFTE |
| 217 | FSAVALCKAA***** |
| 61 | QHENFRKKQIEELKG |
| 67 | KKQIEELKGQEVSPK |
| 74 | KGQEVSPKVYFMKQT |
Function
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity
Protein Sequence
10
MQLKPMEINP
20
EVLTRLGVAG
30
HWRFADVLGL
40
EEESLGSVPA
50
PACALLLLFP
60
LTAQHENFRK
70
KQIEELKGQE
80
VSPKVYFMKQ
90
TIGNSCGTIG
100
LIHAVANNQD
110
KLEFEDGSVL
120
KQFLSETEKL
130
SPEDRAKCFE
140
KNEAIQAAHD
150
AVAQEGQCRV
160
DDKVNFHFIL
170
FNNVDGHLYE
180
LDGRMPFPVN
190
HGASSEDSLL
200
QDAAKVCREF
210
TEREQGEVRF
SAVALCKAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.