Overview
| Uniprot ID | A0A4X1UY74 |
| Protein Name | Chromodomain-helicase-DNA-binding protein 8 |
| Gene Name | CHD8_tv1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 532 |
SKTKGKSKLNTITPV |
Function
ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription
Protein Sequence
10
MADPIMDLFD
20
DPNLFGLDSL
30
TDDSFNQVTQ
40
DPIEEALGLP
50
SSLDSLDQMN
60
QDGGGGDVGN
70
SSASDLVPPP
80
EETTPTELPK
90
ESAAPAPESL
100
TLHDYTTQPV
110
SQEQPAQPVL
120
QTPTPTSGLL
130
QVSKSQEILS
140
QGNPFMGVSA
150
TAVSSSSAGG
160
QPSQSAPKIV
170
ILKAPPSSSV
180
TGAHVAQIQA
190
QGITSTAQPL
200
VAGTANGGKV
210
TFTKVLTGTP
220
LRPGVSIVSG
230
NTVLAAKVPG
240
NQATVQRIVQ
250
PSRPVKQLVL
260
QPVKGSAPAG
270
NPGATGPPLK
280
PAVTLTSTPT
290
QGESKRITLV
300
LQQPQSGGPQ
310
GHRHVVLGSL
320
PGKIVLQGNQ
330
LAALTQAKNA
340
QGQPAKVVTI
350
QLQVQQPQQK
360
IQIVPQPPSS
370
QPQPQQPPST
380
QPVALSSVQQ
390
AQIMGPGQGP
400
GQRLSVPLKV
410
VLQPQAGSSQ
420
GASSGLSVVK
430
VLSASEVAAL
440
SSPASSTPHT
450
GGKTGIEENR
460
RLEHQKKQEK
470
ANRIVAEAIA
480
RARARGEQNI
490
PRVLNEDELP
500
SVRPEEEGEK
510
KRRKKSSGER
520
LKEEKPKKSK
530
TSGTSKTKGK
540
SKLNTITPVV
550
GKKRKRNTSS
560
DNSDVEVMPA
570
QSPREDEESS
580
IQKRRSNRQV
590
KRKKYTEDLD
600
IKITDDEEEE
610
EVDVTGPIKT
620
EPILPEPVQE
630
PDGETLPSMQ
640
FFVENPSEED
650
AAIVDKVLSM
660
RIVKKELPSG
670
QYTEAEEFFV
680
KYKNYSYLHC
690
EWATISQLEK
700
DKRIHQKLKR
710
FKTKMAQMRH
720
FFHEDEEPFN
730
PDYVEVDRIL
740
DESHSIDKDN
750
GEPVIYYLVK
760
WCSLPYEDST
770
WELKEDVDEG
780
KIREFKRIQS
790
RHPELKRVNR
800
PQASAWKKLE
810
LSHEYKNRNQ
820
LREYQLEGVN
830
WLLFNWYNRQ
840
NCILADEMGL
850
GKTIQSIAFL
860
QEVYNVGIHG
870
PFLVIAPLST
880
ITNWEREFNT
890
WTEMNTIVYH
900
GSLASRQMIQ
910
QYEMYCKDSR
920
GRLIPGAYKF
930
DALITTFEMI
940
LSDCPELREI
950
EWRCVIIDEA
960
HRLKNRNCKL
970
LDSLKHMDLE
980
HKVLLTGTPL
990
QNTVEELFSL
1000
LHFLEPSQFP
1010
SESEFLKDFG
1020
DLKTEEQVQK
1030
LQAILKPMML
1040
RRLKEDVEKN
1050
LAPKQETIIE
1060
VELTNIQKKY
1070
YRAILEKNFS
1080
FLSKGAGHTN
1090
MPNLLNTMME
1100
LRKCCNHPYL
1110
INGAEEKILT
1120
EFREACHIIP
1130
HDFHLQAMVR
1140
SAGKLVLIDK
1150
LLPKLKAGGH
1160
KVLIFSQMVR
1170
CLDILEDYLI
1180
QRRYLYERID
1190
GRVRGNLRQA
1200
AIDRFSKPDS
1210
DRFVFLLCTR
1220
AGGLGINLTA
1230
ADTCIIFDSD
1240
WNPQNDLQAQ
1250
ARCHRIGQSK
1260
AVKVYRLITR
1270
NSYEREMFDK
1280
ASLKLGLDKA
1290
VLQSMSGRDG
1300
NITGIQQFSK
1310
KEIEDLLRKG
1320
AYAAIMEEDD
1330
EGSKFCEEDI
1340
DQILLRRTTT
1350
ITIESEGKGS
1360
TFAKASFVAS
1370
ENRTDISLDD
1380
PNFWQKWAKK
1390
ADLDMDLLNS
1400
KNNLVIDTPR
1410
VRKQTRHFST
1420
LKDDDLVEFS
1430
DLESEDDERP
1440
RSRRHDRHHT
1450
YGRTDCFRVE
1460
KHLLVYGWGR
1470
WRDILSHGRF
1480
KRRMTERDVE
1490
TICRAILVYC
1500
LLHYRGDENI
1510
KGFIWDLISP
1520
AENGKTKELQ
1530
NHSGLSIPVP
1540
RGRKGKKVKS
1550
QSTFDIHKAD
1560
WIRKYNPDTL
1570
FQDESYKKHL
1580
KHQCNKVLLR
1590
VRMLYYLRQE
1600
VIGDQAEKVL
1610
GGAIASEIDI
1620
WFPVVDQLEV
1630
PTTWWDSEAD
1640
KSLLIGVFKH
1650
GYEKYNTMRA
1660
DPALCFLEKA
1670
GRPDDKAIAA
1680
EHRVLDNFSD
1690
IVEGVDFDKD
1700
CEDPEYKPLQ
1710
GPPKDQDDEG
1720
DPLMMMDEEI
1730
SVIDGDEAQV
1740
TQQPGHLFWP
1750
PGSALTARLR
1760
RLVTAYQRSY
1770
KREQMKIEAA
1780
ERGDRRRRRC
1790
EAAFKLKEIA
1800
RREKQQRWTR
1810
REQTDFYRVV
1820
STFGVEYDPD
1830
TMQFHWDRFR
1840
TFARLDKKTD
1850
ESLTKYFHGF
1860
VAMCRQVCRL
1870
PPAAGDEPPD
1880
PNLFIEPITE
1890
ERASRTLYRI
1900
ELLRRLREQV
1910
LCHPLLEDRL
1920
ALCQPPGPEL
1930
PKWWEPVRHD
1940
GELLRGAARH
1950
GVSQTDCNIM
1960
QDPDFSFLAA
1970
RMNYMQNHQA
1980
GAPAPSLSRC
1990
STPLLHQQYT
2000
SRTASPLPLR
2010
PDAPVEKPPE
2020
ETAAQVPSLE
2030
SLTLKLEHEV
2040
VARSRPTPQD
2050
YEMRVAPSDT
2060
TPLVSRSVPP
2070
VKLEDEDDSD
2080
SELDLSKLSP
2090
SSSSSSSSSS
2100
SSSSTDESED
2110
EKEEKLTADR
2120
SRSKLYDEES
2130
LLSLTMSQDG
2140
FPNEDGEQMT
2150
PELLLLQERQ
2160
RASEWPKDRV
2170
LINRIDLVCQ
2180
AVLSGKWPSS
2190
RRSQEMVTGG
2200
MLGPGNHLLD
2210
SPSLTPGEYG
2220
DSPVPTPRSS
2230
SAASMAEEEV
2240
SAVTTAAAQF
2250
TKLRRGMDEK
2260
EFTVQIKDEE
2270
GLKLTFQKHK
2280
LMANGVMGDG
2290
HPLFHKKKGN
2300
RKKLVELEVE
2310
CMEEPNHLDV
2320
DLETRIPVIN
2330
KVDGTLLVGE
2340
DAPRRAELEM
2350
WLQGHPEFAV
2360
DPRFLAYMED
2370
RRKQKWQRCK
2380
KNNKAELNCL
2390
GMEPVQTANS
2400
RNGKKGHHTE
2410
TVFNRVLPGP
2420
IAPDSSKKRA
2430
RRTRPDLSKM
2440
MALMQGGGTG
2450
SLSLHNTFQH
2460
SSSGLQSVSS
2470
LGHSSATSAS
2480
LPFMPFVMGG
2490
AASSPHVDSS
2500
TMLHHHHHHP
2510
HPHHHHHHHP
2520
GLRATGYPSS
2530
PATTTSGTAL
2540
RLPPLQPEED
2550
EDDEDEDDDD
2560
DLSQGYDSSE
2570
RDFSLIDDPM
2580
MPANSDSSED
ADD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Molecular Function |
GO:0002039 |
p53 binding |
| Biological Process |
GO:0007420 |
brain development |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0048565 |
digestive tract development |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0045945 |
positive regulation of transcription by RNA polymerase III |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
| Cellular Component |
GO:0071339 |
MLL1 complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0140658 |
ATP-dependent chromatin remodeler activity |
| Molecular Function |
GO:0008013 |
beta-catenin binding |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003678 |
DNA helicase activity |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0140002 |
histone H3K4me3 reader activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.