Search Results
Overview
| Uniprot ID | A0A4X1V5G1 |
|---|---|
| Protein Name | F-box-like/WD repeat-containing protein TBL1XR1 |
| Gene Name | TBL1XR1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 95 | RQQAYRDKLAQQQAA |
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation
Protein Sequence
10
MFAYGTQQHH
20
IQGFSHSAFT
30
FGIESHISQS
40
NINGALVPPA
50
ALISIIQKGL
60
QYVEAEVSIN
70
EDGTLFDGRP
80
IESLSLIDAV
90
MPDVVQTRQQ
100
AYRDKLAQQQ
110
AAAAAAAAAA
120
TNQQGSAKNG
130
ENTANGEENG
140
AHTIANNHTD
150
MMEVDGDVEI
160
PPNKAVVLRG
170
HESEVFICAW
180
NPVSDLLASG
190
SGDSTARIWN
200
LSENSTSGST
210
QLVLRHCIRE
220
GGQDVPSNKD
230
VTSLDWNSEG
240
TLLATGSYDG
250
FARIWTKDGN
260
LASTLGQHKG
270
PIFALKWNKK
280
GNFILSAGVD
290
KTTIIWDAHT
300
GEAKQQFPFH
310
SAPALDVDWQ
320
SNNTFASCST
330
DMCIHVCKLG
340
QDRPIKTFQG
350
HTNEVNAIKW
360
DPTGNLLASC
370
SDDMTLKIWS
380
MKQDNCVHDL
390
QAHNKEIYTI
400
KWSPTGPGTN
410
NPNANLMLAS
420
ASFDSTVRLW
430
DVDRGICIHT
440
LTKHQEPVYS
450
VAFSPDGRYL
460
ASGSFDKCVH
470
IWNTQTGALV
480
HSYRGTGGIF
490
EVCWNAAGDK
500
VGASASDGSV
CVLDLRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.