Overview
| Uniprot ID | A0A4X1V6Z6 |
|---|
| Protein Name | Outer mitochondrial transmembrane helix translocase |
|---|
| Gene Name | ATAD1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 112 |
DTVILPIKKKHLFEN |
| 144 |
CGKTLIAKATAKEAG |
| 148 |
LIAKATAKEAGCRFI |
Function
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria. Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane. Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent
Protein Sequence
10
MVHAEAFSRP
20
LSRNEVVGLI
30
FRLTIFGAVT
40
YFTIKWMVDA
50
IDPTRKQKVE
60
AQKQAEKLMK
70
QIGVKNVKLS
80
EYEMSIAAHL
90
VDPLNMHVTW
100
SDIAGLDDVI
110
TDLKDTVILP
120
IKKKHLFENS
130
RLLQPPKGVL
140
LYGPPGCGKT
150
LIAKATAKEA
160
GCRFINLQPS
170
TLTDKWYGES
180
QKLAAAVFSL
190
AIKLQPSIIF
200
IDEIDSFLRN
210
RSSSDHEATA
220
MMKAQFMSLW
230
DGLDTDHSCQ
240
VIVMGATNRP
250
QDLDSAIMRR
260
MPTRFHINQP
270
ALKQREAILK
280
LILKNENVDR
290
HVDLLEVAQE
300
TDGFSGSDLK
310
EMCRDAALLC
320
VREYVNSTSE
330
ESHDEDEIRP
340
VQQQDLHRAI
350
EKMKKSKDAA
360
FQNVLTHVCL
D
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005778 |
peroxisomal membrane |
| Cellular Component |
GO:0045211 |
postsynaptic membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Biological Process |
GO:0140570 |
extraction of mislocalized protein from mitochondrial outer membrane |
| Biological Process |
GO:0007612 |
learning |
| Biological Process |
GO:0007613 |
memory |
| Biological Process |
GO:0051967 |
negative regulation of synaptic transmission, glutamatergic |
| Biological Process |
GO:0002092 |
positive regulation of receptor internalization |
| Biological Process |
GO:0099149 |
regulation of postsynaptic neurotransmitter receptor internalization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.