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Overview

Uniprot IDA0A4X1V8M2
Protein NameMitochondrial pyruvate carrier
Gene NameMPC2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
27 VELLLPEKLRPLYNH

Function

Mediates the uptake of pyruvate into mitochondria

Protein Sequence

10 MSAAGARGLR 20 ATYHRVLDKV 30 ELLLPEKLRP 40 LYNHPAGPRT 50 VFFWAPIMKW 60 GLVCAGLADM 70 ARPAEKLSTA 80 QSAVLMATGF 90 IWSRYSLVII 100 PKNWSLFAVN 110 FFVGTAGASQ 120 LFRIWRYNQE LKAKANK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:7770001 mitochondrial pyruvate carrier complex
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0050833 pyruvate transmembrane transporter activity
Biological Process GO:0006850 pyruvate import into mitochondria

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.