Overview
| Uniprot ID | A0A4X1V9Z6 |
|---|
| Protein Name | Integrator complex subunit 9 |
|---|
| Gene Name | INTS9 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 542 |
PAQPVGGKKRKRASE |
Function
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex
Protein Sequence
10
MLDCGLDMTS
20
TLNFLPLPLV
30
QSPRLSNLPG
40
WSLKDGNAFL
50
DKELKECSGH
60
VFVDSVPEFC
70
LPETELIDLS
80
TVDVILISNY
90
HCMMALPYIT
100
EHTGFTGTVY
110
ATEPTVQIGR
120
LLMEELVNFI
130
ERVPKAQSAS
140
LWKNKDIQRL
150
LPSPLKDAVE
160
VSTWRRCYTM
170
QEVNSALSKI
180
QMVGYSQKIE
190
LFGAVQVTPL
200
SSGYALGSSN
210
WIIQSHYEKV
220
SYVSGSSLLT
230
THPQPMDQAS
240
LKNSDVLILT
250
GLTQIPTANP
260
DGMVGEFCSN
270
LALTVRNGGN
280
VLVPCYPSGV
290
IYDLLECLYQ
300
YIDSAGLSSI
310
PFYFISPVAN
320
SSLEFSQIFA
330
EWLCHNKQTK
340
VYLPEPPFPH
350
AELIQTNKLK
360
HYPSIHGDFS
370
NDFRQPCVVF
380
TGHPSLRFGD
390
VVHFMELWGK
400
SSLNTVIFTE
410
PDFSYLEALA
420
PYQPLAMKCI
430
YCPIDTRLNF
440
IQVSKLLKEV
450
QPLHVVCPEQ
460
YTQPPPAQSH
470
RMDLMIDCQP
480
PAMSYRRAEV
490
LALPFKRRYE
500
KIEIMPELAD
510
SLVPMEIKPG
520
ISLATVSAVL
530
HTKDNKHVLQ
540
PPPRPAQPVG
550
GKKRKRASEE
560
VPDCKVVKPL
570
LSGSIPVEQF
580
VQTLEKHGFS
590
DIKVEDTAKG
600
HIVLLQEAET
610
LIQIEEDSTH
620
IICDNDEMLR
630
VRLRDLVLKF
LQKF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0160232 |
INTAC complex |
| Cellular Component |
GO:0032039 |
integrator complex |
| Biological Process |
GO:0090101 |
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| Biological Process |
GO:0090287 |
regulation of cellular response to growth factor stimulus |
| Biological Process |
GO:0160240 |
RNA polymerase II transcription initiation surveillance |
| Biological Process |
GO:0034472 |
snRNA 3'-end processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.