Search Results

Overview

Uniprot ID	A0A4X1VC81
Protein Name	Dihydropyrimidinase-related protein 2
Gene Name	DPYSL2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
258	YITKVMSKSAAEVIA
270	VIAQARKKGTVVYGE
472	SGRYIPRKPFPDFVY
520	VTPASSAKTSPAKQQ
525	SAKTSPAKQQAPPVR

Function

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis

Protein Sequence

10 MSYQGKKNIP 20 RITSDRLLIK 30 GGKIVNDDQS 40 FYADIYMEDG 50 LIKQIGENLI 60 VPGGVKTIEA 70 HSRMVIPGGI 80 DVHTRFQMPD 90 QGMTSADDFF 100 QGTKAALAGG 110 TTMIIDHVVP 120 EPGTSLLSAF 130 DQWREWADSK 140 SCCDYSLHVD 150 ITEWHKGIQE 160 EMEALVKDHG 170 VNSFLVYMAF 180 KDRFQLTDSQ 190 IYEVLSVIRD 200 IGAIAQVHAE 210 NGDIIAEEQQ 220 RILDLGITGP 230 EGHVLSRPEE 240 VEAEAVNRSI 250 TIANQTNCPL 260 YITKVMSKSA 270 AEVIAQARKK 280 GTVVYGEPIT 290 ASLGTDGSHY 300 WSKNWAKAAA 310 FVTSPPLSPD 320 PTTPDFLNSL 330 LSCGDLQVTG 340 SAHCTFNTAQ 350 KAVGKDNFTL 360 IPEGTNGTEE 370 RMSIIWDKAV 380 VTGKMDENQF 390 VAVTSTNAAK 400 VFNLYPRKGR 410 IAVGSDADLV 420 IWDPDSVKTI 430 SAKTHNSSLE 440 YNIFEGMECR 450 GSPLVVISQG 460 KIVLEDGTLH 470 VTEGSGRYIP 480 RKPFPDFVYK 490 RIKARSRLAE 500 LRGVPRGLYD 510 GPVCEVSVTP 520 KTVTPASSAK 530 TSPAKQQAPP 540 VRNLHQSGFS 550 LSGAQIDDNI 560 PRRTTQRIVA 570 PPGGRANITS LG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0120025	plasma membrane bounded cell projection
Molecular Function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007399	nervous system development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.