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Overview

Uniprot ID	A0A4X1VC97
Protein Name	Dihydropyrimidinase-related protein 2
Gene Name	DPYSL2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
235	YITKVMSKSAAEVIA
247	VIAQARKKGTVVYGE
449	SGRYIPRKPFPDFVY
497	VTPASSAKTSPAKQQ
502	SAKTSPAKQQAPPVR

Function

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis

Protein Sequence

10 MSYQGKKNIP 20 RITSDRLLIK 30 GGKIVNDDQS 40 FYADIYMEDG 50 LIKQIGENLI 60 VPGGVKTIEA 70 HSRMVIPGGI 80 DVHTRFQMPD 90 QGMTSADDFF 100 QGTKAALAGG 110 TTMIIDHVVP 120 EPGTSLLSAF 130 DQWREWADSK 140 SCCDYSLHVD 150 ITEWHKGIQE 160 EMEALVKDHG 170 VNSFLVYMAF 180 KDRFQLTDSQ 190 IYEVLSVIRD 200 IGAIAQVHAE 210 NGDIIAEVEA 220 EAVNRSITIA 230 NQTNCPLYIT 240 KVMSKSAAEV 250 IAQARKKGTV 260 VYGEPITASL 270 GTDGSHYWSK 280 NWAKAAAFVT 290 SPPLSPDPTT 300 PDFLNSLLSC 310 GDLQVTGSAH 320 CTFNTAQKAV 330 GKDNFTLIPE 340 GTNGTEERMS 350 IIWDKAVVTG 360 KMDENQFVAV 370 TSTNAAKVFN 380 LYPRKGRIAV 390 GSDADLVIWD 400 PDSVKTISAK 410 THNSSLEYNI 420 FEGMECRGSP 430 LVVISQGKIV 440 LEDGTLHVTE 450 GSGRYIPRKP 460 FPDFVYKRIK 470 ARSRLAELRG 480 VPRGLYDGPV 490 CEVSVTPKTV 500 TPASSAKTSP 510 AKQQAPPVRN 520 LHQSGFSLSG 530 AQIDDNIPRR 540 TTQRIVAPPG GRANITSLG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0120025	plasma membrane bounded cell projection
Molecular Function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007399	nervous system development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.