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Overview

Uniprot IDA0A4X1VCL1
Protein Name26S proteasome regulatory subunit 7
Gene NamePSMC2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
100 LQVARCTKIINADSE
110 NADSEDPKYIINVKQ
116 PKYIINVKQFAKFVV
186 GCKEQIEKLREVVET
248 IGSELVQKYVGEGAR
356 EGRTHIFKIHARSMS
407 RRKIATEKDFLEAVN
418 EAVNKVIKSYAKFSA
422 KVIKSYAKFSATPRY
58 DIQQLLKKINELTGI

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

Protein Sequence

10 MPDYLGADQR 20 KTKEDEKDDK 30 PIRALDEGDI 40 ALLKTYGQST 50 YSRQIKQVED 60 DIQQLLKKIN 70 ELTGIKESDT 80 GLAPPALWDL 90 AADKQTLQSE 100 QPLQVARCTK 110 IINADSEDPK 120 YIINVKQFAK 130 FVVDLSDQVA 140 PTDIEEGMRV 150 GVDRNKYQIH 160 IPLPPKIDPT 170 VTMMQVEEKP 180 DVTYSDVGGC 190 KEQIEKLREV 200 VETPLLHPER 210 FVNLGIEPPK 220 GVLLFGPPGT 230 GKTLCARAVA 240 NRTDACFIRV 250 IGSELVQKYV 260 GEGARMVREL 270 FEMARTKKAC 280 LIFFDEIDAI 290 GGARFDDGAG 300 GDNEVQRTML 310 ELINQLDGFD 320 PRGNIKVLMA 330 TNRPDTLDPA 340 LMRPGRLDRK 350 IEFSLPDLEG 360 RTHIFKIHAR 370 SMSVERDIRF 380 ELLARLCPNS 390 TGAEIRSVCT 400 EAGMFAIRAR 410 RKIATEKDFL 420 EAVNKVIKSY 430 AKFSATPRYM TYN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000932 P-body
Cellular Component GO:0008540 proteasome regulatory particle, base subcomplex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0036402 proteasome-activating activity
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.