Search Results
Overview
| Uniprot ID | A0A4X1VDN4 |
|---|---|
| Protein Name | Chloride intracellular channel protein |
| Gene Name | CLIC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 131 | ALNDNLEKGLLKALK |
| 135 | NLEKGLLKALKVLDN |
| 192 | HIVQVVCKKYRGFSI |
| 20 | KAGSDGAKIGNCPFS |
| 49 | NVTTVDTKRRTETVQ |
Function
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle
Protein Sequence
10
MAEEQPQVEL
20
FVKAGSDGAK
30
IGNCPFSQRL
40
FMVLWLKGVT
50
FNVTTVDTKR
60
RTETVQKLCP
70
GGQLPFLLYG
80
TEVHTDTNKI
90
EEFLEAVLCP
100
PRYPKLAALN
110
PESNTAGLDI
120
FAKFSAYIKN
130
SNPALNDNLE
140
KGLLKALKVL
150
DNYLTSPLPE
160
EVDETSAEDE
170
GISQRKFLDG
180
NELTLADCNL
190
LPKLHIVQVV
200
CKKYRGFSIP
210
DAFRGVHRYL
220
RNAYAREEFA
230
STCPDDEEIE
240
LAYEQVAKAL
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034707 | chloride channel complex |
| Molecular Function | GO:0045174 | glutathione dehydrogenase (ascorbate) activity |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005254 | chloride channel activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.