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Overview

Uniprot IDA0A4X1VF00
Protein NameRNA-binding protein 3
Gene NameRBM3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
84 IRVDHAGKSARGTRG

Function

Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation

Protein Sequence

10 MSSEEGKLFV 20 GGLNFNTDEQ 30 ALEDHFSSFG 40 PISEVVVVKD 50 RETQRSRGFG 60 FITFTNPEHA 70 SNAMRAMNGE 80 SLDGRQIRVD 90 HAGKSARGTR 100 GGAFGARGRG 110 YSRGGGDQGY 120 GNGRYDSRPG 130 GYGYGYGYGR 140 SRDYGSSQGS 150 YDRYSGGNYR DNYDN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0043023 ribosomal large subunit binding
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0006417 regulation of translation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.