Search Results

Overview

Uniprot IDA0A4X1VG91
Protein NameStructural maintenance of chromosomes protein
Gene NameSMC4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1273 YKTYNITKSVAVNPK
207 SGKKKTFKDVGNLLR
268 GRLNEPIKVLCRRVE
556 PQTECELKEKEKELQ
598 AMNRSRGKVLDAIIQ
607 LDAIIQEKKTGRIPG
698 PRLFDLVKVKDEKIR
911 DKLDKINKQLDECAS
928 TKAQVAIKTADRNLK

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases

Protein Sequence

10 MPRKGTQPST 20 ARRREEGPPQ 30 SPDRTSSDAQ 40 PESPPGCSES 50 RAPATAETPS 60 EEIDNRSLEE 70 ILSSIPPPPP 80 PAMTNEAGAP 90 RLMITHIVNQ 100 NFKSYAGEKI 110 LGPFHKRFSC 120 IIGPNGSGKS 130 NVIDSMLFVF 140 GYRAQKIRSK 150 KLSVLIHNSD 160 EHKDIQSCTV 170 EVHFQKIIDK 180 EGNDYEVVPN 190 SNFYVSRTAY 200 RDNTSVYHIS 210 GKKKTFKDVG 220 NLLRSHGIDL 230 DHNRFLILQG 240 EVEQIAMMKP 250 KGQTEHDEGM 260 LEYLEDIIGS 270 GRLNEPIKVL 280 CRRVEILNEH 290 RGEKLNRVKM 300 VEKEKDALEG 310 EKNIAIEFLT 320 LENEIFRKKN 330 HVCQYYIYDL 340 QKRIAEMETQ 350 KEKIHEDTKE 360 INEKSNILSN 370 EMKAKNKAVK 380 DVEKKLNKIT 390 KFIEENKEKF 400 TKLDLEDVQV 410 REKLKHATSK 420 AKKLEKQLQK 430 DKEKVEEFKS 440 IPAKSENIIT 450 ETTTRNNALE 460 KEKEKEEKKL 470 KEVMDSLKQE 480 TQGLQKEKES 490 QEKELMGFSK 500 SVNEARSKMD 510 VAQSELDIYL 520 SRYNTAVSQL 530 SKAKDALMAA 540 SETLKERKAA 550 IGDIEAKLPQ 560 TECELKEKEK 570 ELQKLTQEEI 580 NFKSLVRDLF 590 QKVEEAKSSL 600 AMNRSRGKVL 610 DAIIQEKKTG 620 RIPGIYGRLG 630 DLGAIDEKYD 640 VAISSCCHAL 650 DYIVVDSIDT 660 AQECVNFLKR 670 QNIGVATFIG 680 LDKMAVWAKK 690 MTQIQTPENT 700 PRLFDLVKVK 710 DEKIRQAFYF 720 ALRDTLVADN 730 LDQATRVAYQ 740 KDRRWRVVTL 750 QGQIIEQSGT 760 MTGGGSKVMK 770 GRMGSSVVVE 780 ISEEEVNKME 790 SQLQRDSQKA 800 VQIQEHKVQL 810 EETVVKLRHS 820 EREMRNTLEK 830 FTASIQRLSE 840 QEEYLRVQVK 850 ELEANVLATA 860 PDQKKQKLLE 870 ENVNAFKAEY 880 DSVAEKAGKV 890 EAEVKRLHNI 900 IVEINNHKLK 910 AQQDKLDKIN 920 KQLDECASAI 930 TKAQVAIKTA 940 DRNLKKAQDS 950 VFRTEKEIKD 960 TEKEVDDLTT 970 ELKSLEDKAA 980 EVIKNTNAAE 990 ESLPEIQKEH 1000 RSLLQELKVI 1010 QENEHALQKD 1020 ALSIKLKLEQ 1030 IDGHIGEHNS 1040 KIKYWQKEIS 1050 KISLHPIEDN 1060 PVEEIAVLTP 1070 EDLEAIKNPD 1080 SITNQIALLE 1090 AQCHEMKPNL 1100 GAIVEYKKKE 1110 ELYLQRVAEL 1120 DKITYERDNF 1130 RQAYEDLRKQ 1140 RLNEFMAGFY 1150 IITNKLKENY 1160 QMLTLGGDAE 1170 LELVDSLDPF 1180 AEGIMFSVRP 1190 PKKSWKKIFN 1200 LSGGEKTLSS 1210 LALVFALHHY 1220 KPTPLYFMDE 1230 IDAALDFKNV 1240 SIVAFYIYEQ 1250 TKNAQFIIIS 1260 LRNNMFEISD 1270 RLIGIYKTYN 1280 ITKSVAVNPK EIASKGLC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0000796 condensin complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003697 single-stranded DNA binding
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0051301 cell division
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0071707 immunoglobulin heavy chain V-D-J recombination
Biological Process GO:0045132 meiotic chromosome segregation
Biological Process GO:0007076 mitotic chromosome condensation
Biological Process GO:1905821 positive regulation of chromosome condensation
Biological Process GO:0051984 positive regulation of chromosome segregation
Biological Process GO:1905820 positive regulation of chromosome separation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.