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Overview

Uniprot IDA0A4X1VGA2
Protein NameStructural maintenance of chromosomes protein
Gene NameSMC4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1222 YKTYNITKSVAVNPK
207 SGKKKTFKDVGNLLR
268 GRLNEPIKVLCRRVE
556 PQTECELKEKEKELQ
598 AMNRSRGKVLDAIIQ
607 LDAIIQEKKTGRIPG
698 PRLFDLVKVKDEKIR
860 DKLDKINKQLDECAS
877 TKAQVAIKTADRNLK

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases

Protein Sequence

10 MPRKGTQPST 20 ARRREEGPPQ 30 SPDRTSSDAQ 40 PESPPGCSES 50 RAPATAETPS 60 EEIDNRSLEE 70 ILSSIPPPPP 80 PAMTNEAGAP 90 RLMITHIVNQ 100 NFKSYAGEKI 110 LGPFHKRFSC 120 IIGPNGSGKS 130 NVIDSMLFVF 140 GYRAQKIRSK 150 KLSVLIHNSD 160 EHKDIQSCTV 170 EVHFQKIIDK 180 EGNDYEVVPN 190 SNFYVSRTAY 200 RDNTSVYHIS 210 GKKKTFKDVG 220 NLLRSHGIDL 230 DHNRFLILQG 240 EVEQIAMMKP 250 KGQTEHDEGM 260 LEYLEDIIGS 270 GRLNEPIKVL 280 CRRVEILNEH 290 RGEKLNRVKM 300 VEKEKDALEG 310 EKNIAIEFLT 320 LENEIFRKKN 330 HVCQYYIYDL 340 QKRIAEMETQ 350 KEKIHEDTKE 360 INEKSNILSN 370 EMKAKNKAVK 380 DVEKKLNKIT 390 KFIEENKEKF 400 TKLDLEDVQV 410 REKLKHATSK 420 AKKLEKQLQK 430 DKEKVEEFKS 440 IPAKSENIIT 450 ETTTRNNALE 460 KEKEKEEKKL 470 KEVMDSLKQE 480 TQGLQKEKES 490 QEKELMGFSK 500 SVNEARSKMD 510 VAQSELDIYL 520 SRYNTAVSQL 530 SKAKDALMAA 540 SETLKERKAA 550 IGDIEAKLPQ 560 TECELKEKEK 570 ELQKLTQEEI 580 NFKSLVRDLF 590 QKVEEAKSSL 600 AMNRSRGKVL 610 DAIIQEKKTG 620 RIPGIYGRLG 630 DLGAIDEKYD 640 VAISSCCHAL 650 DYIVVDSIDT 660 AQECVNFLKR 670 QNIGVATFIG 680 LDKMAVWAKK 690 MTQIQTPENT 700 PRLFDLVKVK 710 DEKIRQAFYF 720 ALRDTLVADN 730 LDQATRVAYQ 740 KDRRWRVVTL 750 QGQIIEQSGT 760 MTGGGSKVMK 770 GRMGSSVVVE 780 ISEEERLSEQ 790 EEYLRVQVKE 800 LEANVLATAP 810 DQKKQKLLEE 820 NVNAFKAEYD 830 SVAEKAGKVE 840 AEVKRLHNII 850 VEINNHKLKA 860 QQDKLDKINK 870 QLDECASAIT 880 KAQVAIKTAD 890 RNLKKAQDSV 900 FRTEKEIKDT 910 EKEVDDLTTE 920 LKSLEDKAAE 930 VIKNTNAAEE 940 SLPEIQKEHR 950 SLLQELKVIQ 960 ENEHALQKDA 970 LSIKLKLEQI 980 DGHIGEHNSK 990 IKYWQKEISK 1000 ISLHPIEDNP 1010 VEEIAVLTPE 1020 DLEAIKNPDS 1030 ITNQIALLEA 1040 QCHEMKPNLG 1050 AIVEYKKKEE 1060 LYLQRVAELD 1070 KITYERDNFR 1080 QAYEDLRKQR 1090 LNEFMAGFYI 1100 ITNKLKENYQ 1110 MLTLGGDAEL 1120 ELVDSLDPFA 1130 EGIMFSVRPP 1140 KKSWKKIFNL 1150 SGGEKTLSSL 1160 ALVFALHHYK 1170 PTPLYFMDEI 1180 DAALDFKNVS 1190 IVAFYIYEQT 1200 KNAQFIIISL 1210 RNNMFEISDR 1220 LIGIYKTYNI 1230 TKSVAVNPKE IASKGLC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000796 condensin complex
Cellular Component GO:0031981 nuclear lumen
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:0051301 cell division
Biological Process GO:0030261 chromosome condensation
Biological Process GO:0098813 nuclear chromosome segregation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.