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Overview

Uniprot IDA0A4X1VH73
Protein NameCasein kinase II subunit beta
Gene NameCSNK2B
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
197 VHPEYRPKRPANQFV

Function

Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling

Protein Sequence

10 MEKCKGTSNR 20 MAGATSAEVK 30 MSSSEEVSWI 40 SWFCGLRGNE 50 FFCEVDEDYI 60 QDKFNLTGLN 70 EQVPHYRQAL 80 DMILDLEPDE 90 ELEDNPNQSD 100 LIEQAAEMLY 110 GLIHARYILT 120 NRGIAQMLEK 130 YQQGDFGYCP 140 RVYCENQPML 150 PIGLSDIPGE 160 AMVKLYCPKC 170 MDVYTPKSSR 180 HHHTDGAYFG 190 TGFPHMLFMV 200 HPEYRPKRPA 210 NQFVPRLYGF 220 KIHPMAYQLQ 230 LQAASNFKSP VKTIR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0031519 PcG protein complex
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0016605 PML body
Cellular Component GO:0005956 protein kinase CK2 complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0019887 protein kinase regulator activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0033211 adiponectin-activated signaling pathway
Biological Process GO:0061154 endothelial tube morphogenesis
Biological Process GO:0043537 negative regulation of blood vessel endothelial cell migration
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:1903901 negative regulation of viral life cycle
Biological Process GO:0032927 positive regulation of activin receptor signaling pathway
Biological Process GO:0060391 positive regulation of SMAD protein signal transduction
Biological Process GO:0075342 symbiont-mediated disruption of host cell PML body
Biological Process GO:0016055 Wnt signaling pathway

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.