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Overview

Uniprot IDA0A4X1VHA5
Protein NameStructural maintenance of chromosomes protein
Gene NameSMC4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1226 YKTYNITKSVAVNPK
207 SGKKKTFKDVGNLLR
268 GRLNEPIKVLCRRVE
509 PQTECELKEKEKELQ
551 AMNRSRGKVLDAIIQ
560 LDAIIQEKKTGRIPG
651 PRLFDLVKVKDEKIR
864 DKLDKINKQLDECAS
881 TKAQVAIKTADRNLK

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases

Protein Sequence

10 MPRKGTQPST 20 ARRREEGPPQ 30 SPDRTSSDAQ 40 PESPPGCSES 50 RAPATAETPS 60 EEIDNRSLEE 70 ILSSIPPPPP 80 PAMTNEAGAP 90 RLMITHIVNQ 100 NFKSYAGEKI 110 LGPFHKRFSC 120 IIGPNGSGKS 130 NVIDSMLFVF 140 GYRAQKIRSK 150 KLSVLIHNSD 160 EHKDIQSCTV 170 EVHFQKIIDK 180 EGNDYEVVPN 190 SNFYVSRTAY 200 RDNTSVYHIS 210 GKKKTFKDVG 220 NLLRSHGIDL 230 DHNRFLILQG 240 EVEQIAMMKP 250 KGQTEHDEGM 260 LEYLEDIIGS 270 GRLNEPIKVL 280 CRRVEILNEH 290 RGEKLNRVKM 300 VEKEKDALEG 310 EKNIAIEFLT 320 LENEIFRKKN 330 HVCQYYMKLN 340 KITKFIEENK 350 EKFTKLDLED 360 VQVREKLKHA 370 TSKAKKLEKQ 380 LQKDKEKVEE 390 FKSIPAKSEN 400 IITETTTRNN 410 ALEKEKEKEE 420 KKLKEVMDSL 430 KQETQGLQKE 440 KESQEKELMG 450 FSKSVNEARS 460 KMDVAQSELD 470 IYLSRYNTAV 480 SQLSKAKDAL 490 MAASETLKER 500 KAAIGDIEAK 510 LPQTECELKE 520 KEKELQKLTQ 530 EEINFKSLVR 540 DLFQKVEEAK 550 SSLAMNRSRG 560 KVLDAIIQEK 570 KTGRIPGIYG 580 RLGDLGAIDE 590 KYDVAISSCC 600 HALDYIVVDS 610 IDTAQECVNF 620 LKRQNIGVAT 630 FIGLDKMAVW 640 AKKMTQIQTP 650 ENTPRLFDLV 660 KVKDEKIRQA 670 FYFALRDTLV 680 ADNLDQATRV 690 AYQKDRRWRV 700 VTLQGQIIEQ 710 SGTMTGGGSK 720 VMKGRMGSSV 730 VVEISEEEVN 740 KMESQLQRDS 750 QKAVQIQEHK 760 VQLEETVVKL 770 RHSEREMRNT 780 LEKFTASIQR 790 LSEQEEYLRV 800 QVKELEANVL 810 ATAPDQKKQK 820 LLEENVNAFK 830 AEYDSVAEKA 840 GKVEAEVKRL 850 HNIIVEINNH 860 KLKAQQDKLD 870 KINKQLDECA 880 SAITKAQVAI 890 KTADRNLKKA 900 QDSVFRTEKE 910 IKDTEKEVDD 920 LTTELKSLED 930 KAAEVIKNTN 940 AAEESLPEIQ 950 KEHRSLLQEL 960 KVIQENEHAL 970 QKDALSIKLK 980 LEQIDGHIGE 990 HNSKIKYWQK 1000 EISKISLHPI 1010 EDNPVEEIAV 1020 LTPEDLEAIK 1030 NPDSITNQIA 1040 LLEAQCHEMK 1050 PNLGAIVEYK 1060 KKEELYLQRV 1070 AELDKITYER 1080 DNFRQAYEDL 1090 RKQRLNEFMA 1100 GFYIITNKLK 1110 ENYQMLTLGG 1120 DAELELVDSL 1130 DPFAEGIMFS 1140 VRPPKKSWKK 1150 IFNLSGGEKT 1160 LSSLALVFAL 1170 HHYKPTPLYF 1180 MDEIDAALDF 1190 KNVSIVAFYI 1200 YEQTKNAQFI 1210 IISLRNNMFE 1220 ISDRLIGIYK 1230 TYNITKSVAV 1240 NPKEIASKGL C

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000796 condensin complex
Cellular Component GO:0031981 nuclear lumen
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:0051301 cell division
Biological Process GO:0030261 chromosome condensation
Biological Process GO:0098813 nuclear chromosome segregation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.