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Overview

Uniprot ID	A0A4X1VID6
Protein Name	Mitochondrial import inner membrane translocase subunit TIM44
Gene Name	TIMM44
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
102	EEAAKTAKQSAESVS
66	TGEVIRKKLGEITGT

Function

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source

Protein Sequence

10 MAAAALRGGW 20 CRCPRRCFSS 30 GVHFLSRHNL 40 VPLPLGTYQM 50 PWPSGQQTLR 60 TIESETMRTG 70 EVIRKKLGEI 80 TGTVKESLDE 90 VSKSDLGRKI 100 KEGVEEAAKT 110 AKQSAESVSK 120 GGEKLGRTAA 130 FKALSQGVES 140 VKKEIDESVL 150 GQTGPYRRPE 160 RLRKRKEFAG 170 EKFKEEKVFE 180 ANEEALGVVL 190 HKDSKWYQQW 200 KDFRDNNVVF 210 NRFFEMKMKY 220 DESDNALIRA 230 SRVLTDKVTD 240 LLGGLFSKTE 250 MSEVLTEILR 260 VDPAFDKERF 270 LQQCENDIIP 280 NVLEAMISGE 290 LDILKDWCYE 300 ATYSQLAHPI 310 QQAKALGLQF 320 HSRILDIDNI 330 DLAMGKMMEQ 340 GPVLIITFQA 350 QLVMVIKNPK 360 GEVVEGDPDK 370 VLRMLYVWAL 380 CRDQDELNPY 390 AAWRLLDISA SSTEQVL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0051087	protein-folding chaperone binding
Biological Process	GO:0030150	protein import into mitochondrial matrix

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.