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Overview

Uniprot IDA0A4X1VMN9
Protein NameElectron transfer flavoprotein subunit beta
Gene NameETFB
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
115 AKLAQKEKVDLVLLG
58 LKEKKLVKEVIAVSC

Function

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role

Protein Sequence

10 NFHMRAWLSP 20 KRIPLGMQIR 30 VKPDRTGVVM 40 DGVKHSMNPF 50 CEIAVEEAVR 60 LKEKKLVKEV 70 IAVSCGPAQC 80 QETIRTALAM 90 GADRGIHVEV 100 PAAEAHHLGP 110 LQVARVLAKL 120 AQKEKVDLVL 130 LGKQAIDDDC 140 NQTGQMTAGF 150 LDWPQGTFAS 160 QVTLEGDKVK 170 VEREIDGGLE 180 TLRLKLPAVV 190 TADLRLNEPR 200 YATLPNIMKA 210 KKKKIEVIKA 220 GDLGVDLTSK 230 LSVVSVEDPP 240 QRVAGVKVET 250 TEDLVAKLRE IGRI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045251 electron transfer flavoprotein complex
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0009055 electron transfer activity
Biological Process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.