Overview
| Uniprot ID | A0A4X1VQD7 |
|---|
| Protein Name | Set1/Ash2 histone methyltransferase complex subunit ASH2 |
|---|
| Gene Name | ASH2L |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 307 |
KGRGAKRKQQDGGTT |
Function
Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May play a role in hematopoiesis. In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B
Protein Sequence
10
MAAAGTGPGP
20
GVGAGTGPTA
30
AVNATPAEEG
40
ETKPVAAVAA
50
APAGEGTSVT
60
PAAEPVSGEA
70
ESGDANSVDV
80
SGGLETESSN
90
GKDTLEGAGD
100
TSEVMDTQAG
110
SVDEENGRQL
120
GEVELQCGIC
130
TKWFTADTFG
140
IDTSSCLPFM
150
TNYSFHCNVC
160
HHSGNTYFLR
170
KQANLKEMCL
180
SALANLTWQS
190
RTQDEHPKTM
200
FSKDKDIIPF
210
IDKYWECMTT
220
RQRPGKMTWP
230
NNIVKTMSKE
240
RDVFLVKEHP
250
DPGSKDPEED
260
YPKFGLLDQD
270
LSNIGPAYDN
280
QKQSSTVSTS
290
GNLNGGASFG
300
GGIAAGSSGK
310
GRGAKRKQQD
320
GGTTGTTKKA
330
RSDPLFSAQR
340
LPPHGYPLEH
350
PFNKDGYRYI
360
LAEPDPHAPD
370
PEKLELDCWA
380
GKPIPGDLYR
390
ACLYERVLLA
400
LHDRAPQLKI
410
SDDRLTVVGE
420
KGYSMVRASH
430
GVRKGAWYFE
440
ITVDEMPPDT
450
AARLGWSQPL
460
GNLQAPLGYD
470
KFSYSWRSKK
480
GTKFHQSIGK
490
HYSSGYGQGD
500
VLGFYINLPE
510
DTETAKSLPD
520
TYKDKALIKF
530
KSYLYFEEKD
540
FVDKAEKSLK
550
QTPHSEIIFY
560
KNGVNQGVAY
570
KDIFEGVYFP
580
AISLYKSCTV
590
SINFGPCFKY
600
PPKDLAYRPM
610
SDMGWGAVVE
620
HTLADVLYHV
630
ETEVDGRRSP
PWEP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071339 |
MLL1 complex |
| Cellular Component |
GO:0044666 |
MLL3/4 complex |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0048188 |
Set1C/COMPASS complex |
| Molecular Function |
GO:0008013 |
beta-catenin binding |
| Molecular Function |
GO:0008168 |
methyltransferase activity |
| Molecular Function |
GO:0000976 |
transcription cis-regulatory region binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0032259 |
methylation |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0043627 |
response to estrogen |
| Biological Process |
GO:0045815 |
transcription initiation-coupled chromatin remodeling |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.