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Overview

Uniprot ID	A0A4X1VR06
Protein Name	Nucleolar GTP-binding protein 2
Gene Name	GNL2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
334	INTLRSKKVCNVAPI

Function

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels

Protein Sequence

10 MVKPKYKGRS 20 TINPSNASTN 30 PDRVQGAGGQ 40 NMRDRATIRR 50 LNMYRQKERR 60 NSRGKVIKPL 70 QYQSTVASGT 80 VARVEPNIKW 90 FGNTRVIKQS 100 SLQKFQEEMD 110 TVLKDPYKVV 120 MKQSKLPMSL 130 LHDRIRPHNS 140 KVHILDTESF 150 ETTFGPKAQR 160 KRPNLFASDM 170 QSLIENAEMS 180 TESYDQGKDR 190 DLVAEDTGVR 200 NEAQEEIYKK 210 GQSKRIWGEL 220 YKVIDSSDVV 230 VQVLDARDPM 240 GTRSPHIETY 250 LKKEKPWKHL 260 IFVLNKCDLV 270 PTWATKRWVA 280 VLSQDHPTLA 290 FHASLTNPFG 300 KGAFIQLLRQ 310 FGKLHTDKKQ 320 ISVGFIGYPN 330 VGKSSVINTL 340 RSKKVCNVAP 350 IAGETKVWQY 360 ITLMRRIFLI 370 DCPGVVYPSE 380 DSETDIVLKG 390 VVQVEKIKTP 400 EDHIGAVLER 410 AKPEYISKTY 420 KIDSWENAED 430 FLEKLAFRTG 440 KLLKGGEPDL 450 RTVGKMVLND 460 WQRGRIPFFV 470 KPPNAEPPAT 480 PQLPSASTLE 490 VAPETAQNNT 500 EEETPESGGG 510 GSEPGLEKKE 520 EEPGQCGADA 530 EMQQILARVR 540 QNFGKINVVP 550 QFSGDDLVPL 560 EMSDIEEELE 570 SLSGEREEEE 580 EQEPQEDTDE 590 EPFTEAQEEH 600 TGSSTKAVIQ 610 ALDEKIAKYQ 620 RFLDKAKAKK 630 FSAVRISKGL 640 SEKVFAKPEQ 650 QKAVEEDVED 660 TAPTKKGKKR 670 KAQREEEHSD 680 KTRRMLTSKE 690 RRRAARQQQP 700 RKVGVRYYET 710 HNVKNRNRNK 720 KKTSDSEGQK 730 QRRKKFKHKQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Molecular Function	GO:0005525	GTP binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.