Search Results
Overview
| Uniprot ID | A0A4X1VRN9 |
|---|---|
| Protein Name | Ubiquitin-fold modifier-conjugating enzyme 1 |
| Gene Name | UFC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | AKMYRGGKICLTDHF |
Function
E2-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy)
Protein Sequence
10
MADEATRRVV
20
SEIPVLKTNA
30
GPRDRELWVQ
40
RLKEEYQSLI
50
RVIGLRRFVL
60
CYRWFGKCWY
70
IHDLLKYEFD
80
IEFDIPITYP
90
TTAPEIAVPE
100
LDGKTAKMYR
110
GGKICLTDHF
120
KPLWARNVPK
130
FGLAHLMALG
140
LGPWLAVEIP
150
DLIQKGVIQH
KEKCNQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0061657 | UFM1 conjugating enzyme activity |
| Biological Process | GO:0071569 | protein ufmylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.