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Overview

Uniprot IDA0A4X1VS57
Protein NameElongation factor 2
Gene NameEEF2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
244 YVAKFAAKGEGQLGP
257 GPAERAKKVEDMMKK
263 KKVEDMMKKLWGDRY
277 YFDPANGKFSKSATS
280 PANGKFSKSATSPDG
313 FDAIMNFKKEETAKL
319 FKKEETAKLIEKLDI
323 ETAKLIEKLDIKLDS
327 LIEKLDIKLDSEDKD
333 IKLDSEDKDKEGKPL
335 LDSEDKDKEGKPLLK
338 EDKDKEGKPLLKAVM
342 KEGKPLLKAVMRRWL
37 IAHVDHGKSTLTDSL
391 DEAAMGIKSCDPKGP
412 KMVPTSDKGRFYAFG
431 GLVSTGLKVRIMGPN
444 PNYTPGKKEDLYLKP
450 KKEDLYLKPIQRTIL
47 LTDSLVCKAGIIASA
503 AHNMRVMKFSVSPVV
517 VRVAVEAKNPADLPK
576 DHACIPIKKSDPVVS
577 HACIPIKKSDPVVSY
599 SNVLCLSKSPNKHNR
624 GLAEDIDKGEVSARQ
643 RARYLAEKYEWDVAE

Function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome

Protein Sequence

10 MAKGKESKTL 20 VDQIRAIMDK 30 KANIRNMSVI 40 AHVDHGKSTL 50 TDSLVCKAGI 60 IASARAGETR 70 FTDTRKDEQE 80 RCITIKSTAI 90 SLFYELSEND 100 LNFIKQSKDG 110 SGFLINLIDS 120 PGHVDFSSEV 130 TAALRVTDGA 140 LVVVDCVSGV 150 CVQTETVLRQ 160 AIAERIKPVL 170 MMNKMDRALL 180 ELQLEPEELY 190 QTFQRIVENV 200 NVIISTYGEG 210 ESGPMGNIMI 220 DPVLGTVGFG 230 SGLHGWAFTL 240 KQFAEMYVAK 250 FAAKGEGQLG 260 PAERAKKVED 270 MMKKLWGDRY 280 FDPANGKFSK 290 SATSPDGKKL 300 PRTFCQLILD 310 PIFKVFDAIM 320 NFKKEETAKL 330 IEKLDIKLDS 340 EDKDKEGKPL 350 LKAVMRRWLP 360 AGDALLQMIT 370 IHLPSPVTAQ 380 KYRCELLYEG 390 PPDDEAAMGI 400 KSCDPKGPLM 410 MYISKMVPTS 420 DKGRFYAFGR 430 VFSGLVSTGL 440 KVRIMGPNYT 450 PGKKEDLYLK 460 PIQRTILMMG 470 RYVEPIEDVP 480 CGNIVGLVGV 490 DQFLVKTGTI 500 TTFEHAHNMR 510 VMKFSVSPVV 520 RVAVEAKNPA 530 DLPKLVEGLK 540 RLAKSDPMVQ 550 CIIEESGEHI 560 IAGAGELHLE 570 ICLKDLEEDH 580 ACIPIKKSDP 590 VVSYRETVSE 600 ESNVLCLSKS 610 PNKHNRLYMK 620 ARPFPDGLAE 630 DIDKGEVSAR 640 QELKQRARYL 650 AEKYEWDVAE 660 ARKIWCFGPD 670 GTGPNILTDI 680 TKGVQYLNEI 690 KDSVVAGFQW 700 ATKEGALCEE 710 NMRGVRFDVH 720 DVTLHADAIH 730 RGGGQIIPTA 740 RRCLYASVLT 750 AQPRLMEPIY 760 LVEIQCPEQV 770 VGGIYGVLNR 780 KRGHVFEESQ 790 VAGTPMFVVK 800 AYLPVNESFG 810 FTADLRSNTG 820 GQAFPQCVFD 830 HWQILPGDPF 840 DNTSRPSQVV 850 AETRKRKGLK 860 EGIPALDNFL DKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0005840 ribosome
Cellular Component GO:0045202 synapse
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0106222 lncRNA binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0043022 ribosome binding
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0006414 translational elongation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.