Search Results
Overview
| Uniprot ID | A0A4X1VSC7 |
|---|---|
| Protein Name | Ubiquitin-fold modifier-conjugating enzyme 1 |
| Gene Name | UFC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | AKMYRGGKICLTDHF |
Function
E2-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy)
Protein Sequence
10
MADEATRRVV
20
SEIPVLKTNA
30
GPRDRELWVQ
40
RLKEEYQSLI
50
RYVENNKNAD
60
NDWFRLESNK
70
EGTRWFGKCW
80
YIHDLLKYEF
90
DIEFDIPITY
100
PTTAPEIAVP
110
ELDGKTAKMY
120
RGGKICLTDH
130
FKPLWARNVP
140
KFGLAHLMAL
150
GLGPWLAVEI
160
PDLIQKGVIQ
HKEKCNQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0061657 | UFM1 conjugating enzyme activity |
| Molecular Function | GO:0071568 | UFM1 transferase activity |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:1990592 | protein K69-linked ufmylation |
| Biological Process | GO:0032649 | regulation of type II interferon production |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
| Biological Process | GO:0061709 | reticulophagy |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.