Overview
| Uniprot ID | A0A4X1VU90 |
|---|
| Protein Name | Stomatin-like protein 2, mitochondrial |
|---|
| Gene Name | STOML2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 175 |
AINVAEGKKQAQILA |
| 176 |
INVAEGKKQAQILAS |
| 204 |
EASAVLAKAKAKAEA |
| 94 |
TMRSELGKLSLDKVF |
| 99 |
LGKLSLDKVFRERES |
Function
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation
Protein Sequence
10
MLARAARGTG
20
ALLLRGLNIL
30
IPVLDRIRYV
40
QSLKEIVINV
50
PEQSAVTLDN
60
VTLQIDGVLY
70
LRIMDPYKAS
80
YGVEDPEYAV
90
TQLAQTTMRS
100
ELGKLSLDKV
110
FRERESLNAS
120
IVDAINQAAD
130
CWGIRCLRYE
140
IKDIHVPPRV
150
KESMQMQVEA
160
ERRKRATVLE
170
SEGTRESAIN
180
VAEGKKQAQI
190
LASEAEKAEQ
200
INQAAGEASA
210
VLAKAKAKAE
220
AIRILAAALT
230
QHNGDAAASL
240
TVAEQYVSAF
250
SKLAKDSNTI
260
LLPSNPGDVT
270
SMVAQAMGVY
280
GALTKAPVPG
290
PQDSVSSRSS
300
RDVQGTDASL
310
DEELDRVKLS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.