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Overview

Uniprot IDA0A4X1VUI2
Protein NameTransportin-3
Gene NameTNPO3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
827 GAVTVTHKQLTDFHK
834 KQLTDFHKQVTSAEE

Function

Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus

Protein Sequence

10 MKMKIQTSFY 20 ELPTDSHASL 30 RDSLLTHIQN 40 LKDLSPVIVT 50 QLALAIADLA 60 LQMPSWKGCV 70 QTLVEKYSND 80 VTSLPFLLEI 90 LTVLPEEVHS 100 RSLRIGANRR 110 TEIIEDLAFY 120 SSTVVSLLMT 130 CVEKAGTDEK 140 MLMKVFRCLG 150 SWFNLGVLDS 160 NFMANNKLLA 170 LLFEVLQQDK 180 TSSNLHEAAS 190 DCVCSALYAI 200 ENVETNLPLA 210 MQLFQGVLTL 220 ETAYHMAVAR 230 EDLDKVLNYC 240 RIFTELCETF 250 LEKIVCTPGQ 260 GLGDLRTLEL 270 LLICAGHPQY 280 EVVEISFNFW 290 YRLGEHLYKT 300 NDEVIHGIFK 310 AYIQRLLHAL 320 ARHCQLEPDH 330 EGVPEETDDF 340 GEFRMRVSDL 350 VKDLIFLIGS 360 MECFAQLYST 370 LKEGNPPWEV 380 TEAVLFIMAA 390 IAKSVDPENN 400 PTLVEVLEGV 410 VRLPETVHTA 420 VRYTSIELVG 430 EMSEVVDRNP 440 QFLDPVLGYL 450 MKGLCEKPLA 460 SAAAKAIHNI 470 CSVCRDHMAQ 480 HFNGLLEIAR 490 SLDSFMLSPE 500 AAVGLLKGTA 510 LVLARLPLDK 520 ITECLSELCS 530 VQVMALKKLL 540 SQEPSNGISS 550 DPTVFLDRLA 560 VIFRHTNPIV 570 ENGQTHPCQK 580 VIQEIWPVLS 590 ETLNKHRADN 600 RIVERCCRCL 610 RFAVRCVGKG 620 SAALLQPLVT 630 QMVNVYHVHQ 640 HSCFLYLGSI 650 LVDEYGMEEG 660 CRQGLLDMLQ 670 ALCIPTFQLL 680 EQQNGLQNHP 690 DTVDDLFRLA 700 TRFIQRSPVT 710 LLRSQVVIPI 720 LQWAIASTTL 730 DHRDANCSVM 740 RFLRDLIHTG 750 VANDHEEDFE 760 LRKELIGQVM 770 NQLGQQLVSQ 780 LLHTCCFCLP 790 PYTLPDVAEV 800 LWEIMQVDRP 810 TFCRWLENSL 820 KGLPKETTVG 830 AVTVTHKQLT 840 DFHKQVTSAE 850 ECKQVCWALR DFTRLFR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005635 nuclear envelope
Biological Process GO:0006606 protein import into nucleus

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.