Search Results
Overview
| Uniprot ID | A0A4X1VVT9 |
|---|---|
| Protein Name | Erlin |
| Gene Name | ERLIN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 192 | LMESEKTKLLIAAQK |
| 199 | KLLIAAQKQKVVEKE |
| 287 | YLQLMKYKAIASNSK |
Function
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex
Protein Sequence
10
MAQLGAVVAV
20
AASFFCASLF
30
SAVHKIEEGH
40
IGVYYRGGAL
50
LTSTSGPGFH
60
LMLPFITSYK
70
SVQTTLQTDE
80
VKNVPCGTSG
90
GVMIYFDRIE
100
VVNFLVPHAV
110
YDIVKNYTAD
120
YDKALIFNKI
130
HHELNQFCSV
140
HTLQEVYIEL
150
FDQIDENLKL
160
ALQQDLTSMA
170
PGLVIQAVRV
180
TKPNIPEAIR
190
RNYELMESEK
200
TKLLIAAQKQ
210
KVVEKEAETE
220
RKKALIEAEK
230
VAQVAEITYG
240
QKVMEKETEK
250
KISEIEDAAF
260
LAREKAKADA
270
ECYTAMKIAE
280
ANKLKLTPEY
290
LQLMKYKAIA
300
SNSKIYFGKD
310
IPNMFMDSAG
320
SLGKQFEGLT
330
DKLSFGLEDE
PLEAGTEEN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0045541 | negative regulation of cholesterol biosynthetic process |
| Biological Process | GO:0045717 | negative regulation of fatty acid biosynthetic process |
| Biological Process | GO:0032933 | SREBP signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.