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Overview

Uniprot IDA0A4X1VZI2
Protein Name26S proteasome non-ATPase regulatory subunit 13
Gene NamePSMD13
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
105 EKTREKVKSSDEAVI
174 GNHASYYKDALRFLG
298 LTFEEIAKSAKITVN
31 RLEELYTKKLWHQLT
329 GSIDEVDKRVHMTWV

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MKDVPGFLQQ 20 SQSSGPGQAA 30 VWHRLEELYT 40 KKLWHQLTLQ 50 VLDFVQDPCF 60 AQGDGLIKLY 70 ENFISEFEHR 80 VNPLSLVEII 90 LHVVRQMTDP 100 NVALTFLEKT 110 REKVKSSDEA 120 VILCKTAIGA 130 LKLNIGDLQV 140 TKETIEDVEE 150 MLSSLPGVTS 160 VHSRFYDLSS 170 KYYQTIGNHA 180 SYYKDALRFL 190 GCVDIKDLPV 200 SEQQERAFTL 210 GLAGLLGEGV 220 FNFGELLMHP 230 VLESLRDTDR 240 QWLIDTLYAF 250 NSGNVERFQT 260 LKTAWGQQPD 270 LAANEAQLLR 280 KIQLLCLMEM 290 TFTRPANHRQ 300 LTFEEIAKSA 310 KITVNEVELL 320 VMKALSVGLV 330 KGSIDEVDKR 340 VHMTWVQPRV 350 LDLQQIRGMK 360 DRLEFWCTDV 370 KSMEMLVEHQ AHDILT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0008541 proteasome regulatory particle, lid subcomplex
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.