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Overview

Uniprot IDA0A4X1W1S1
Protein NameStaphylococcal nuclease domain-containing protein
Gene NameSND1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
149 AECEEQAKAAKKGMW
169 SQTIRDLKYTIENPR
185 FVDSHHQKPVNAIIE
331 PTANLDQKDKQFVAK
333 ANLDQKDKQFVAKVM
358 KLNSGDYKTIHLSSI
378 EGENTQDKNKKLRPL
406 RKKLIGKKVNVTVDY
489 GKGLHSKKEVPIHRV
505 DISGDTQKAKQFLPF
507 SGDTQKAKQFLPFLQ
533 VFSGSRLKLYLPKET
63 AATQPDAKDTPDEPW
633 AERSSYYKSLLSAEE
643 LSAEEAAKQKKEKVW
744 WYRARVEKVESPAKV
750 EKVESPAKVHVFYID
878 LNAQESAKSARLNLW
94 VCFTIENKTPQGREY

Function

Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5

Protein Sequence

10 AEYCSGGWGH 20 NSGPSVLPVL 30 SGCAIIVRGQ 40 PRGGPPPERQ 50 INLSNIRAGN 60 LARRAAATQP 70 DAKDTPDEPW 80 AFPAREFLRK 90 KLIGKEVCFT 100 IENKTPQGRE 110 YGMIYLGKDT 120 NGENIAESLV 130 AEGLATRREG 140 MRANNPEQNR 150 LAECEEQAKA 160 AKKGMWSEGS 170 GSQTIRDLKY 180 TIENPRHFVD 190 SHHQKPVNAI 200 IEHVRDGSVV 210 RALLLPDYYL 220 VTVMLSGIKC 230 PTFRREADGS 240 ETPEPFAAEA 250 KFFTESRLLQ 260 RDVQIILESC 270 HNQNILGTIL 280 HPNGNITELL 290 LKDGFARCVD 300 WSIAVYTRGA 310 EKLRAAERFA 320 KDRRLRIWRD 330 YVAPTANLDQ 340 KDKQFVAKVM 350 QVLNADAIVV 360 KLNSGDYKTI 370 HLSSIRPPRL 380 EGENTQDKNK 390 KLRPLYDIPY 400 MFEAREFLRK 410 KLIGKKVNVT 420 VDYIRPASPA 430 TETVPAFSER 440 TCATVTIGGI 450 NIAEALVSKG 460 LATVIRYRQD 470 DDQRSSHYDE 480 LLAAEARAIK 490 NGKGLHSKKE 500 VPIHRVADIS 510 GDTQKAKQFL 520 PFLQRAGRSE 530 AVVEYVFSGS 540 RLKLYLPKET 550 CLITFLLAGI 560 ECPRGARNLP 570 GLVQEGEPFS 580 EEATLFTKEL 590 VLQREVEVEV 600 ESMDKAGNFI 610 GWLHIDGANL 620 SVLLVEHALS 630 KVHFTAERSS 640 YYKSLLSAEE 650 AAKQKKEKVW 660 AHYEEQPVEE 670 VAPMLEEKER 680 SASYKPVFVT 690 EITDDLHFYV 700 QDVETGTQLE 710 KLMENMRNDI 720 ASHPPVEGSY 730 APRRGEFCIA 740 KFVDGEWYRA 750 RVEKVESPAK 760 VHVFYIDYGN 770 REILPSTRLG 780 TLPPAFSTRV 790 LPAQATEYAF 800 AFIQVPQDED 810 ARTDAVDSVV 820 RDIQNTQCLL 830 NVEHLSAGCP 840 HVTLQFADSK 850 GDVGLGLVKE 860 GLVMVEVRKE 870 KQFQKVITEY 880 LNAQESAKSA 890 RLNLWRYGDF 900 RADDADEFGY SR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031332 RNAi effector complex
Molecular Function GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0004521 RNA endonuclease activity
Biological Process GO:0006402 mRNA catabolic process
Biological Process GO:0031047 regulatory ncRNA-mediated gene silencing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.