Search Results
Overview
| Uniprot ID | A0A4X1W5E4 |
|---|---|
| Protein Name | 26S proteasome non-ATPase regulatory subunit 10 |
| Gene Name | PSMD10 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 221 | GGLGLILKRMVES** |
| 30 | KERILADKSLATRTD |
Function
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis
Protein Sequence
10
MEGCVSNLMV
20
CNLAYSGKLE
30
ELKERILADK
40
SLATRTDQDS
50
RTALHWACSA
60
GHTEIVEFLL
70
QLGVPVNDKD
80
DAGWSPLHIA
90
ASAGRDEIVK
100
ALLGKGAQVN
110
AVNQNGCTPL
120
HYAASKNRHE
130
IAVMLLEGGA
140
NPDAKDHYEA
150
TAMHRAAAKG
160
NLKMIHILLY
170
YKASTNIQDT
180
EGNTPLHLAC
190
DEERVEEAKL
200
LVSQGASIYI
210
ENKEEKTPLQ
220
VAKGGLGLIL
KRMVES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0008540 | proteasome regulatory particle, base subcomplex |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0090201 | negative regulation of release of cytochrome c from mitochondria |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0070682 | proteasome regulatory particle assembly |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.